摘要
目的分析总结经蝶垂体瘤切除术对生长激素腺瘤的疗效观察。方法回顾254例垂体生长激素腺瘤的资料。结果平均病程3.5年。侵袭性腺瘤20例,非侵袭性腺瘤234例。术后复发4例,视力视野改变3例,γ刀治疗后3例。手术采用经单鼻孔或口鼻蝶改良入路,肿瘤全切除和次全切除率85%,生长激素水平恢复正常率87%,血糖改善率81%,死亡率0.8%。50例平均随访54.5个月,生活自理47例,复发4例。术后放疗垂体功能低下发生率62.1%。结论垂体生长激素腺瘤,临床以面容改变、肢端肥大、继发性血糖增高、头痛等为主要症状,经蝶显微手术为首选治疗。需注意放疗后垂体功能低下的并发症。
Objective To analyze the creative effect of transsphenoidal surgery treating the GH - secreting pituitary adenoma. Methods 254 cases of GH - secreting pituitary adencraa are reviewed. Results The mean present history was 3.5 years. The cases include 20 invasive adenoma and 234 non - invasive adenoma. Among the patients, 4 patients were recurrence after operation, 3 patients accompanied by the change of visual acuity and field, 3 had γ- knife previously. The operative approach includes trans - single nares and tram - sphenoidal sinus. The rate of total excision and subtotal excision is 85 %. In 87 % patients the level of GH hormone return to be normal. In 81% patients the blood glucose ameliorate. The mortality is 0.8%. The mean follow- up of 51 patients are 43.5 months, 47 patients self- care and 4 recurrence. 50 % patiens accompanied hypopituitarism after getting postoperative radiotherapy. Conclusion The major symptom of GH - secreting pituitary adenoma include physiognomy change, acromegaly, secondary hyperglycaemia and headache. Transsphenoidal surgery is the primary therapy. The complieation of hypopituitarism after radiotherapy shoud be payed attention.
出处
《宁夏医学杂志》
CAS
2006年第11期816-818,共3页
Ningxia Medical Journal
关键词
垂体生长激素腺瘤
显微手术
糖尿病
GH - secreting pituitary odenomas
Microsurgery
Diabetes mellitus
