摘要
目的 评估利福昔明片治疗急性感染性腹泻的临床疗效及安全性。方法 采用多中心、随机、双盲双模拟、阳性药物平行对照的方法，入选240例患者，试验组120例服用利福昔明片，第1天300mg，3次／d；第2-5天400mg，2次／d；对照组120例服用左氧氟沙星片，第1天100mg，3次／d；第2～5天100mg，2次／d，疗程为3-5d。结果 试验组治疗3-5d后，腹痛腹泻及大便检查恢复正常或明显好转，痊愈率84．68％．显效率15．31％，总有效率为100．00％，细菌清除率为100．00％，与对照组比较P〉0．05，两组均未见严重不良反应。结论 利福昔明片是治疗急性感染性腹泻安全有效的药物。
OBJECTIVE To evaluate the clinical curative effect and safety of rifaximin in treating acute infectious diarrhea. METHODS A multi-center randomized trial with double-blind double-analogue and parallel-control with positive drug was used. All the 240 chosen patients were classified into two groups. There were 120 cases in the trial group. On the first day, the patients received rifaximin 300rag rid. From the 2nd to 5th day, the patients received rifaximin 400 mg rid. There were 120 cases in the control group, on the first day, the patients received levofloxacin 100 mg tid; from 2nd to 5th day,they received levofloxacin 100 mg rid. The total therapeutic course was 3 to 5 days. RESULTS After 3-5 day treatment, symptoms such as ache in abdomen and diarrhea were alleviated or disappeared and stool examination was turned better or normally. To the trial group, the cure rate was 84.68%, the dominant effecive rate was 15.31M, and the total effective rate was 100.00M. The bacteria clearance rate was 100.00% in the trial group. There was no significant difference between two groups. There were no severe side effect in the two groups. CONCLUSIONS Rifaximin is an effective and safe drug for acute infectious diarrhea for adults.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第11期1280-1282,共3页
Chinese Journal of Nosocomiology
