摘要
为探讨盐敏感性高血压病患者盐负荷后的肾脏病理生理特征，观察了４７例高血压病患者基础及盐负荷情况下的肾排钠反应、血浆肾素活性（ＰＲＡ）、前列环素（ＰＧＩ２）水平等的改变，以及盐负荷时静注血管紧张素Ⅱ（ＡｎｇⅡ）对对－氨基马尿酸（ＰＡＨ）及肾皮质有效血浆流量（ＥＲＰＦ）的影响。发现２９例盐敏感者中有２０例呈＂增强型＂肾排钠反应。另９例呈相对＂低减型＂肾排钠反应。盐敏感者基础排钠量及盐负荷后肾排钠总量均明显高于盐不敏感者。＂低减型＂排钠盐敏感者具有盐负荷后ＰＲＡ不被抑制、肾排钠减少、ＥＲＰＦ无相应增加以及血压反应增强的特点。提示该型患者与＂非调节型＂的病理生理特征基本相同。
To identify the renal pathophysiological features to acute salt load in salt-sensitive Hypertensive, 47 hospitalized patients with essential hypertension were enrolled,the renal sodium excretion response, plasma renin activity (PRA), plasma PGI2 level、and the changes of P-Aminohippurae clearance rate(PAH)and effective renal plasma flow (ERPF)to venous angiotensin Ⅱ(Ang Ⅱ) injection were measured before and after saline load.The salt-sensitive patients(SS, 29 cases)were further divided into exaggerated (20 cases)and decreased(9 cases)sodium excretion groups.The SS had higher sodium excretion(whether basal of after saline load)than that of salt resistant (SR)patients (P<0.05).The SS with decreased renal sodium excretion(SSd)were characterized with attenuated renin suppression , decreased renal sodium excretion, no significant increasing in ERPF and enhanced blood pressure response after saline load.The data suggested that the pathophysiological features of 'decrease'subgroup in SS were similar to those of 'non-modulators' in hypertensives.
出处
《西安医科大学学报》
CSCD
1996年第2期131-135,共5页
Journal of Xi'an Medical University(Chinese)
基金
国家八.五攻关及自然科学基金
关键词
高血压病
盐敏感性
肾脏
病理生理特征
Essential hypertension
salt sensitivity
kidney
pathophysiological features
