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大鼠糖尿病痛过敏模型的建立 被引量:5

THE SETTING UP OF A RAT MODEL OF DIABETIC HYPERALGESIA
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摘要 用腹腔注射链尿佐菌素(STZ)建立糖尿病大鼠模型,然后观察其体重、血糖和运动神经传导速度(MNCV)的变化,并以伤害性爪回缩反射和甩尾反射为痛指标测量痛阈。结果表明:腹腔注射STZ后,大鼠血糖升高(血糖>11.1mmol/L),体重增长迟缓,MNCV减慢;实验至第1周时,甩尾反射潜伏期(TFL)显著缩短,第2周时,伤害性爪回缩阈值(NPWT)明显降低。上述结果提示,大鼠已产生糖尿病,并处于痛过敏状态。 After rats were intraperioneally injected with streptozotocin(STZ),their body weight, blood glucose, motor nerve conduction velocity(MNCV), tail flick latency (TFL)and nociceptive paw-withdrawal threshold(NPWT)were observed systematically.The results showed that in the group of rats blood glucose increased(blood glucose>11.1mmol/L), body weigh slowly grew and MNCV reduced.At the first week of the exoperiment,TFL significantly reduced,at the second week,NPWT reduced,too.The above results suggest that the rats have suffered from diabetes,and they have developed hyperalgesia.
出处 《西安医科大学学报》 CSCD 1996年第2期136-139,共4页 Journal of Xi'an Medical University(Chinese)
关键词 糖尿病 痛过敏 链脲佐菌素 大鼠 diabetes hyperalgesia streptozotocin rat
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  • 1杨秀伟,王多佳.四氧嘧啶性糖尿病与自由基反应[J].国外医学(内分泌学分册),1994,14(3):144-146. 被引量:18
  • 2谢利剑,沈媛,黄国英,赵晓晴,杨毅,周国民.CMV43^(CT)转基因小鼠心血管发育的形态学研究[J].复旦学报(医学版),2005,32(3):259-262. 被引量:3
  • 3贾雪梅,王惠珠,齐易祥,陆云,王道斌.实验性糖尿病对小鼠肝脏酶组织化学和超微结构的影响[J].解剖学杂志,1995,18(5):451-454. 被引量:8
  • 4于德民,吴锐,尹潍,袁咏.实验性链脲佐菌素糖尿病动物模型的研究[J].中国糖尿病杂志,1995,3(2):105-109. 被引量:425
  • 5Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes [J]. Pain, 1997,73(2):123-139.
  • 6Syriatowicz JP, Hu D, Walker JS, et al. Hyperalgesia due to nerve injury: role of prostaglandins [J]. Neuroscience, 1999,94(2):587-594.
  • 7Britland ST, Young RJ, Sharma AK, et al. Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fiber pathology [J]. Pain, 1992,48(3):361-370.
  • 8Chen X, Levine JD. Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat [J]. Neuroscience, 2001,102(1):185-192.
  • 9Chen XJ, Tanner K, Levine JD. Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat [J]. Neurosci Lett, 1999,267(1):105-108.
  • 10Ma WY, Eisenach JC. Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation [J]. Exp Neurol, 2003,183(3):581-592.

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