摘要
采用密度梯度法对28例妊高征孕妇及28例正常晚期妊娠妇女外周血中的循环内皮细胞(CEC),进行了数量及形态学的初步观察。在28例妊高征中,轻度9例,中度8例,重度11例。结果显示:妊高征孕妇血中的 CEC 数、CEC 聚集体率和 CEC 聚集体数,产前分别是(16.6±9.3)个/0.9μl、85.7%、(2.7±2.9)个/0.9μl。产后分别是(15.6±7.1)个/0.9μl、78.6%、(2.1±1.8)个/0.9μl。产前及产后均显著高于正常晚期妊娠妇女(P<0.001～0.05)。且重度妊高征孕妇较轻、中度妊高征者显著增高(P<0.01～0.05)。说明妊高征孕妇因血管内皮细胞(VEC)的损伤而致 VEC 脱落增加,致使外周血中 CEC 增多。因此,可将外周血中 CEC 的变化作为妊高征患者的临床监测指标,对妊高征的诊断及治疗均有参考价值。
To determine whether the content of circulating endothelial cells(CEC)from peripheral blood was increased in patients with PIH.Design:28 PIH and 28 health pregnant women(HPW)who were in the third trimester were studied.The CEC from pe- ripheral blood were obtained by PVP-silica density gradients.The CEC count and the shape of CEC were studied.The count and the rate of aggregation of CEC were observed.Results:The CEC count,the rate and the count of aggregation of CEC were(16.6±9.3)n/ 0.9μ1,85.7%,(2.7±2.9)n/0.9μl respectively before childbearing and(15.6±7.1)n/0.9μl,78.6%,(2.1± 1.8)n/0.9μl after childbearing in PIH;While in HPW,they were(8.7±3.3)n/0.9μl,53.6%,(0.7± 0.9)n/0.9μl respectively before childbearing and(9.1 ±4.7)n/0.9μl,42.9%,(0.9±1.18)n/0.9μl after childbearing.The CEC count,the rate and the count of aggregation of CEC in PIH were higher than those in HPW(P<0.05 ).Conclusion:The damage of vascular endothelium indeed existed in PIH.The abnormality can induce the desquamation of vascular endothelium and the increase of CEC in peripheral blood.The study indicated that the changes of CEC in peripheral blood were useful targets for diagnosing and treating PIH.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
1996年第4期211-212,共2页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
妊娠高血压
综合征
循环内皮细胞
Circulating endothelial cells Vascular endothelium
Pregnancy-induced hyper-tension
