摘要
随着医学领域各种新观念、新方法、新技术的不断涌现,对妇科恶性肿瘤的临床诊治和基础研究均得到了长足发展。循证医学、个体化治疗以及微创治疗的引入和发展使我们对各种妇科恶性肿瘤的诊治更趋向于规范化,在提高治疗效果的同时,尽量减少患者的创伤,提高生活质量。对妇科恶性肿瘤的基础研究发现促性腺激素在肿瘤的发生发展中可能起重要作用,雌激素可能通过PAX2基因促进癌细胞的生长。细胞凋亡抑制蛋白Survivin可能在调控肿瘤细胞增殖和凋亡中起关键作用。
With the emergence of new concepts, methods and techniques in modern medicine, the basic research and clinical treatment for gynecological oncology has rapidly developed in the past couple of years. Evidence-based medicine, individualized therapy and microinvasive therapy give us more opportunities to treat the patient. Nowadays, it is possible for the clinic to implement new approaches to improve the outcome and the quality of life for the patients with minimal side effects at the same time. There has been a lot of reports from in vitro studies suggesting that gonadotrophin may play an important role in tumorigenesis, estrogen may promote tumor cell proliferation through PAX2 gene. Survivin, a protein serving as an apoptosis inhibitor, may be crucial for the regulation of tumor cell proliferation and apoptosis.
出处
《中国癌症杂志》
CAS
CSCD
2006年第11期881-885,共5页
China Oncology
关键词
妇科恶性肿瘤
治疗
基础研究
gynecological oncology
treatment
basic research
