摘要
用激光微循环血流仪研究了急性脑缺血沙鼠经１００～４００ｋＰａ氧压暴露对脑膜微循环的影响。结果显示，脑缺血动物高压氧暴露后脑膜细动、静脉血流速度明显加快，与对照组相比有非常显著差异（Ｐ＜０．０１）。提示高压氧具有改善微循环血流动力学的作用。实验观察到，经２５０ｋＰａ和３００ｋＰａ氧压暴露６０ｍｉｎ后对微循环血流速度的改善以及对血管扩张的扼制作用优于在１００ｋＰａ氧压暴露６０ｍｉｎ和４００ｋＰａ氧压暴露３０ｍｉｎ方案。结合以往工作。
Influence of hyperbaric oxygen exposure (HBOE) at 100～400kPa in 47 gerbils with cerebral ischemia were studied with a Laser micrl-blood flow meter. Results showed that velocity of blood flow in meninx arteriolae and venulae were clealy increased after HBOE. Comparision between the HBOE groups and control group, there were very significant difference ( P <0.01). It suggest that hyperbaric oxygen plays a role in improving microcirculation hemodynamics. The experiment obsearved between the velocity increase and the antagonist on angiotasis after HBOE at 250 and 300kPa were better than that of the HBOE at 100kPa/60 min and 400kPa/30min. All of Results suggest that the scheme of HBOE at 260～300kPa/60min could be the best one among the pressure-time courses in HBO during cerebral ischemia.
出处
《微循环学杂志》
1996年第2期7-9,共3页
Chinese Journal of Microcirculation
基金
中国人民解放军总后勤部卫生部科研基金
关键词
脑缺血
脑膜微循环
氧压
高压氧治疗
Microcirculation
Hyperbaric oxygenation
Cerebral ischemia
Microvessel
Gerbils
