摘要
各种急性与慢性应激时，循环血中及脑、心血管、肾腺等组织中血管紧张素Ⅱ（ＡⅡ）显著增多；人剧烈运动后血浆ＡⅡ与皮质醇一样均剧烈增加，在慢性应激性高血压动物循环及组织中，ＡⅡ含量持续地增高。还发现高浓度ＡⅡ对肾上腺糖皮质激素的分泌有直接的刺激作用，而组织ＡⅡ增多又受肾上腺素能β受体的激发。根据近年来的系列工作，并结合文献，我们认为ＡⅡ是一种重要的应激激素；肾素－血管紧张素系统是一个应激激素反应系统；它与经典的应激激素反应系统，下丘脑－垂体－肾上腺皮质系统及交感－肾上腺髓质系统也存在着密切的关系。
Angiotensin Ⅱ (A Ⅱ ) was significantly increased in both acutely and chronicallystressed animals as found in brain, heart, blood vessels and adrenal glands. After running a race, the plasma A Ⅱ contents of sportsmen similar to cortisol increased markedly too. In the chronical stress-hypertensive animals, the contents of circulating A Ⅱ andtissue A Ⅱ were increased quite lastingly. It was also found that the high concentrationof A Ⅱ may stimulate the adrenal gland secreting glucosteroid, and increase of tissue AⅡ may be faciliated by the activation of beta adrenergic receptors. On basis of theabove finding, we tend to assume that A Ⅱ is a stress hormone and the renin angiotension system (RAS) is a stress hormone responses system. Morever there exists a closerelation between RAS and two classic stress hormone response systems, i. e. the hypothalamus-pituitary-adrenal cortex system and the sympathetic-adrenal medulla system
出处
《生理学报》
CAS
CSCD
北大核心
1996年第6期521-528,共8页
Acta Physiologica Sinica
关键词
血管紧张素
应激
肾素
血管紧张素系统
ngiotensin
stress
renin-angiotensin-system
cortisol
hypothalamus-pituitary-adrenalcortex
sympathetic-adrenal medulla system
stress hormone responses system
