摘要
目的:制备绿原酸-β-环糊精包合物并验证。方法:采用研磨法制备包合物,并通过均匀设计实验得到最佳制备条件;用紫外扫描和差示扫描量热法对包合物进行验证。结果:以包合率和载药量为指标筛选出最佳包合条件:即摩尔比绿原酸∶β-环糊精=1∶1,温度25℃,研磨60 min;确定包合物已经形成。结论:利用研磨法制备绿原酸-β-环糊精包合物,是可行的。
Object： To prepare and confirm the inclusion complex of chlorogenic acid andSβ- cyclodextrin. Methods： The inclusion complex was prepared by trituration. The optimal inclusion technique, was selected by homogeneous design. The inclusion complex was confirmed by UV and DSC scan. Results： According to the drug loading and trapping efficiency, the optimal inclusion techniques was that molecular ration of chlorogenic acid toβ- cyclodextrin was 1 ： 1, temperature was 25℃ and trituration time was 60 min. In the above conditions, the inclusion complex was formed. Conclusion： It is feasible that the inclusion complex was prepared by trituration.
出处
《天津药学》
2006年第5期25-27,共3页
Tianjin Pharmacy
关键词
绿原酸
Β-环糊精
包合物
chlorogenic acid, β- cyclodextrin, inclusion complex
