摘要
目的观察加味逍遥散汤剂中当归来源的阿魏酸在肝郁脾虚证患者体内的药代动力学特征。方法选取肝郁脾虚证患者10例,测定患者在口服加味逍遥散汤剂5、10、15、30、60、90、120 m in的血清样本中阿魏酸的浓度。结果肝郁脾虚证患者阿魏酸的血药浓度-时间曲线符合二室开放模型,其吸收半衰期为(15.61±9.77)m in,分布半衰期为(41.54±23.95)m in,消除半衰期为(91.01±64.14)m in。结论明确阿魏酸在肝郁脾虚证患者体内的药代动力学特征,为临床用药提供一定的参考作用。
Objective To observe the pharmacokinetic characteristics of ferulic acid （from Radix Angelicae Sinensis ） of decocted Jiaweixiaoyao Powder in patients with liver-qi stagnation and spleen insufficiency. Methods Ten patients with liver-qi stagnation and spleen insufficiency were chosen and given Jiaweixiaoyao Powder orally. At the time of 5, 10, 15,30, 60, 90 and 120 min, the concentration of ferulic acid in the serum samples was determined. Results The concentration-time curve of ferulic acid in serum of patients with liver-qi stagnation and spleen insufficiency was shown to fit a double compartment open model, t1/2Ka was （ 15.61 ± 9.77） min, t1/2α was （41.54 ± 23.95） min, and t1/2 was （91. 01 ± 64. 14 ） min. Conclusion The pharmacokinetic characteristics of ferulic acid is understood in the serum of patients with liver-qi stagnation and spleen insufficiency, which will play a reference role in clinical application.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2006年第10期694-697,712,共5页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(No.39770886)
高等学校骨干教师资助计划
关键词
阿魏酸
加味逍遥散
肝郁脾虚证
药代动力学
ferulic acid
Jiaweixiaoyao Powder
syndrome of liver-qi stagnation and spleen insufficiency
phannacokinetics
