期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肌成纤维细胞与肾小球硬化 被引量：2

Myofibroblast and Glomerulosclerosis
下载PDF
导出
摘要 肌成纤维细胞是一种超微结构介于平滑肌细胞和成纤维细胞之间的细胞,具有很强的分泌细胞外基质及收缩的功能,在组织创伤愈合、纤维化形成等方面发挥重要的作用。本文就肌成纤维细胞的特征,及其在肾小球硬化形成发展中的作用和意义等方面进行综述。 The myofibroblast is an cell having strong function in secretion of estracelluar matrix and constraction, whose uhrastructure is just between that of fibroblast and smooth muscle cell. which plays an important role in wound healing and fibrosis development. In this review, we summaried the myofibroblast about its character and its effect and significant in the development of glomerulosclerosis.
作者 裴娟 覃远汉
机构地区 广西医科大学第一附属医院儿科
出处 《医学综述》 2006年第22期1348-1350,共3页 Medical Recapitulate
基金 广西科学基金项目(桂科自0640103)
关键词 肌成纤维细胞 肌动蛋白 肾小球硬化 内皮细胞 Myofibroblast Actin Glomerulosclerosis Endothelial cell
分类号 R692.6 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

  • 1Gabbiani G,Ryan GB,Majne G.Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction[J].Experientia,1971,27 (5):549-550.
  • 2Desmoulière A,Darby IA,Gabbiani G.Normal and pathologic soft tissue remodeling:role of the myofibroblast,with special emphasis on liver and kidney fibrosis[J].Lab Invest,2003,83(12):1689-1707.
  • 3Tomasek JJ,Gabbiani G,Hinz B,et al.Myofibroblasts and mechanoregulation of connective tissue remodelling[J].Nat Rev Mol Cell Biol,2002,3(5):349-363.
  • 4Ng YY,Fan JM,Mu W,et al.Glomerular epithelial-myofibroblast transdifferentiation in the evolution of glomerular crescent formation[J].Nephrol Dial Transplant,1999,14(12):2860-2872.
  • 5Fujigaki Y,Sun DF,Fujimoto T,et al.Mechanisms and kinetics of Bowman's epithelial-myofibroblast transdifferentiation in the formation of glomerular crescents[J].Nephron,2002,92(1):203-212.
  • 6Johnson RJ,Lida H,Alper CE,et al.Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis[J].J Clin Invest,1991,87 (3):847-858.
  • 7Patel K,Harding P,Haney LB,et al.Regulation of the mesangial cell myofibroblast phenotype by actin polymerization[J].J Cell Physiol,2003,195 (3):435 -445.
  • 8Ohashi R,Shimizu A,Masuda Y,et al.P.eritubular Capillary Regression during the Progression of Experimental Obstructive Nephropathy[J].J Am Soo Nephrol,2002,13(7):1795-1805.
  • 9Sommer M,Gerth J,Stein G,et al.Transdifferentiation of endothelial and renal tubular epithelial cells into myofibroblast-like cells under in vitro conditions:a morphological analysis[J].Cells Tissues Organs,2005,180(4):204-214.
  • 10Goumenos D,Tsomi K,Iatrou C,et al.Myofibroblasts and the progression of crescentic glomerulonephritis[J].Nephrol Dial Transplant,1998,13(7):1652-1661.

二级参考文献9

  • 1MAO Y,OOTAKA T,SAITO T,et al.The involvement of advanced glycation endproducts (AGEs) in renal injury of diabetic glomerulosclerosis:association with phenotypic change in renal cells and infiltration of immune cells [J].Clin Exp Nephrol,2003,7(3):201-209.
  • 2ISOGA I S,MOGAM I K,SHINA N,et al.Initial ultras-tructural changes in pore size and anionic sites of the glomerular basement membrane in streptozotocin induced diabetic rats and their prevention by insulin treatment [J].Nephron,1999,83(1):53-59.
  • 3SANAI T,SOBKA T,JOHSON T,et al.Expression of cytoskeletal proteins during the course of experimental diabetic nephropathy [J].Diabetologia,2000,43:91-100.
  • 4MATTHEW D, OLDFIELD L, LEON A, et al. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products(RAGE) [J].J Clin Invest,2001,108:1853-1863.
  • 5MEZZANOSA,AROS C A,DROGUETT A,et al.Renal angiotensionⅡup regulation and myofibroblast activation in human membranous nephropathy [J].Kindney International,2003,10:s39-s45.
  • 6ARORA P D,NARANI N,MCCULLOCH A G.The compliance of collagengels regulates transforming growth factor-βinduction of alpha-smooth muscle actin in fibroblasts [J].Am J Pathol,1999,154:871-887.
  • 7李红,郑芬萍,张哲.糖尿病大鼠外周血单个核细胞内与肾皮质中TGF-β_1mRNA水平的相关性研究[J].浙江大学学报（医学版）,2004,33(1):51-54. 被引量：9
  • 8叶迅,李红.转化生长因子β_1和波形蛋白及结蛋白在糖尿病大鼠肾皮质中早期表达的研究[J].浙江大学学报（医学版）,2004,33(1):55-59. 被引量：4
  • 9董凤芹,李红,蔡卫民,陶君,郑芬萍,张哲.糖尿病大鼠肾小球基质金属蛋白酶2和9的表达[J].浙江大学学报（医学版）,2004,33(3):245-249. 被引量：8

共引文献24

同被引文献21

  • 1吴伟华,张巾超,于江波,刘国良.2型糖尿病及合并大血管病变糖尿病患者C反应蛋白水平观察[J].中华内分泌代谢杂志,2003,19(4):257-259. 被引量：68
  • 2沈诚,范士志,陈建明,李志平,何勇.JAK/STAT通路对缺血再灌注心肌NF-κB和TNF-α表达的影响[J].中国现代医学杂志,2006,16(7):985-987. 被引量：19
  • 3Lehmann R, Schleicher ED. Molecular mechanism of Diabetic Nephropathy. Clin Chim Acta,2000,297 ( 1 - 2) :34 - 38.
  • 4Kisseleva T, Bhattacharya S, Braunstein J, et al. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene ,2002,285 ( 1 - 2) :21 - 24.
  • 5Marrero MB, Banes - Berceli AK, Stem DM, et al. Role of the JAK/STAT, signaling pathway in diabetic nephropathy. Am J Physiol Renal Physiol,2006,290 (4) : F762 - 768.
  • 6Aaronson DS, Horvath CM. A road map for those who don, t know JAK/STAT. Science,2002,296 (5573) : 1653 - 1655.
  • 7Jinde K, Nikolic - Pateroson DJ, Huang XR, et al. Tubular phe- notypic chang in progressive tubulointerstitial fibrosis in human glomerulonephritis. Am J Kidney Dis,2001,38(4) :761 - 764.
  • 8Lee S, Sharma K. The pathogenesis of fibrosis and renal disease in scleroderma: recent insights from glomerulosclerosis, Curt Rheumatol Rep, 2004,6 (2) : 141 - 148.
  • 9王剑英,刘俊萍,于为民.来氟米特对糖尿病肾病大鼠PKC表达的影响[J].中国中西医结合肾病杂志,2008,9(10):911-913. 被引量：6
  • 10贺宏英,吴绥生.JAK/STAT信号转导途径研究新进展[J].新医学,2009,40(12):827-830. 被引量：13

引证文献2

二级引证文献36

医学综述
2006年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部