摘要
目的:观察知母、黄柏组方(知柏地黄丸)对解脲脲原体前列腺炎以及解脲脲原体前列腺炎合并精子活力低下患者的治疗作用。方法:选择江门市五邑中医院2004-08/2005-07收治的解脲脲原体前列腺炎患者72例,其中合并精子活力低下者41例,年龄20～40岁。将72例患者数字表法随机分为2组,每组36例:①知柏地黄丸组(合并精子活力低下者22例):口服知柏地黄丸(湖南九芝堂制药有限公司生产,由知母、黄柏、熟地、山茱萸、淮山药、丹皮、泽泻、茯苓组成),每次16丸(相当于原生药6g),早晚各一次,温开水送服。②美满霉素组(合并精子活力低下者19例):口服美满霉素(苏州立达制药有限公司生产),早晚各一次,100mg/次。治疗前和治疗1个月后分别作前列腺液解脲脲原体培养,并观察前列腺液中白细胞;同时观察临床症状变化,根据临床症状和前列腺中白细胞计数评估临床疗效;合并精子活力低下者进行常规精液检查,包括液化时间、精子密度、精子活率、精子畸形率和精子活力(评分越高,活力越强)。结果:72例患者全部进入结果分析。①解脲脲原体转阴率:知柏地黄丸组和美满霉素组比较差异不显著(83%,86%,P>0.05)。②疗效:知柏地黄丸组总有效率高于美满霉素组(89%,72%,P<0.05)。③前列腺液中的白细胞数:治疗后均少于治疗前,但两组比较差异不显著(P>0.05)。④精液检查结果:两组药物均不能改变患者的精子密度;均可使精子的活率和活力增加,在提高精子活力方面,知柏地黄丸优于美满霉素(3.19±0.34,2.53±0.49,P<0.05);同时知柏地黄丸可使患者精液液化时间缩短、精子畸形率下降,而美满霉素则不能。结论:知柏地黄丸能有效地治疗解脲脲原体前列腺炎并能够使合并精子活力低下患者的精子活力提高。
AIM： To observe the therapeutical effect of the prescription composed of common anemarrhena rhizome and amur corktree bark （which is called Zhibaidihuang pill） on patients with prostatitis in M.urealyticum and patients with prostatitis accompanied by asthenospermia.
METHODS： Seventy-two patients with prostatitis in M.ruealyticum were selected from Wuyi TCM Hospital of Jiangmen from August 2004 to July 2005, including 41 patients accompanied by asthenospermia with the age ranged 20-40 years. All enrolled subjects were randomly divided into 2 groups with 36 patients in each group： ① Zhibaidihuang pill group （including 22 patients accompanied by asthenospermia）： Patients were administrated by orally taken Zhibaidihaang pill （manufaetured by Hunan Jiuzhitaug Co., Ltd., and it was composed of common anemarrhena rhizome, amur corktree bark, processed, Fructus Corni, common yam rhizome, danpi, oriental waterplantain rhizome and tuckahoe） with 16 pills each time （which was equal to 6 g of crude drug） twice respectively in the morning and at night by warm boiled water.② Minocycline group （including 19 patients with prostatitis in M.ruealyticum accompanied by asthenospermia）： Patients orally took minocycline （which was manufactured by Suzhou Lida Co., Ltd.） twice a day respectively in the morning and at night with 100 mg each time. Culture of M.urealyticum in prostatic fluid was performed before treatment and one month after the treatment respectively to observe the leucocytes. Meanwhile, the changes in clinical symptoms were observed to evaluate the clinical effect according to the clinical symptoms and the leucocyte numbers in prostatic fluid. Routine semen detection was conducted in patients accompanied by asthenospermia, including the liquefaction time, sperm density, the survival rate of sperm, the deformationrate of sperm and the vitality of sperm （the higher the score was, the stronger the vitality was）.
RESULTS： A total of 72 patients were involved in the analysis of results. ① The negative-conversion rate of M.urealyticum： There was no significant difference between the Zhibaidihuang pill group and the minoeycline group （83% ,86% ,P 〉 0.05）. ② Effect： The total efficiency in the Zhibaidihuang pill group was higher than that in the minocycline group （89% .72% ,P 〈 0.05）.③ The number of leucocytes in prostatic fluid： It was less after the treatment than that before the treatment, While the difference was not remarkable （P 〉 0.05）. ④ Detection of semen： The density of patients＇ sperm didn＇t change under medication treatment with the drugs mentioned above, while the drugs could enhance the survival rate and vitality of sperm, Zhibaidihuaug pill could enhance the vitality of sperm better than minocycline （3.19±0.34,2.53±0.49,P 〈 0.05）. Meanwhile, Zhibaidihuang pill could reduce the liquefaction time of semen; decrease the deformation rate of sperm in patients, while the minocycline could not.
CONCLUSION： Zhibaidihuang pill can effectively treat the prostatitis in M.urealyticum, besides, it can enhance the sperm vitality of patients with asthenospermia.
出处
《中国临床康复》
CSCD
北大核心
2006年第43期76-78,共3页
Chinese Journal of Clinical Rehabilitation
