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高效液相色谱法同时测定复方氨茶碱栓中2组分的含量 被引量:1

Simultaneous Determination of Two Components of Compound Aminophylline Suppository by HPLC
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摘要 目的建立以高效液相色谱法同时测定复方氨茶碱栓中氨茶碱和富马酸酮替芬含量的方法。方法色谱柱为ODS,流动相为甲醇-水(9∶1),流速为1ml/min,柱温为40℃,检测波长为300nm,进样量为20μl。结果氨茶碱、富马酸酮替芬检测浓度分别在500·0~2000·0μg/ml(r=0·9995)、5·0~20·0μg/ml(r=0·9998)范围内与峰面积积分值线性关系良好;平均回收率分别为101·4%(RSD=2·35%)、98·6%(RSD=2·55%)。结论本方法可靠、简便、准确,可用于复方氨茶碱栓的质量控制。 OBJECTIVE: To establish a HPLC method for simultaneous determination of aminophylline and ketotifen fumarate in compound aminophylline suppository.METHODS: The analysis was carried on C18 column; the mobile phase was composed of methanol(9)and water(1);the flow rate was lml/min;the column temperature was 40℃ and the detection wavelength was 300nm.The sample size was 20μl.RESULTS: The liner ranges for aminophylline and ketotifen fumarate were 500.0-2 000.0μg/ ml( r = 0.9 995) and 5.0-20.0μg/ ml(r = 0.9 998), respectively,The average recoveries were 101.4% (RSD = 2.35% ) and 98.6% (RSD = 2.55% ), respectively.CONCLUSION: The method is reliable, simple, accurate and suitable for the quality control of compound aminophylline suppository.
出处 《中国药房》 CAS CSCD 北大核心 2006年第22期1738-1739,共2页 China Pharmacy
关键词 高效液相色谱法 复方氨茶碱栓 氨茶碱 富马酸酮替芬 含量 HPLC Aminophylline combination Aminophylline Ketotifen fumarate Content
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