摘要
目的通过脊髓型颈椎病(CSM)血清免疫球蛋白含量与JOA评分的相关性研究,探讨了体液免疫在CSM发病机制中的作用。方法用散射比浊法检测30例CSM患者血清的IgGI、gAI、gM和补体C3含量;并对30例CSM患者进行JOA评分,同时检测正常对照组20例血清的IgGI、gA、IgM和补体C3含量。结果CSM组患者血清IgG含量明显高于正常对照组(P<0.01);CSM患者在以JOA评分为基准分组中:重、中度组(0～12分)和轻度组(13～17分),两组间血清IgG含量在两组中有差异(P<0.05)。结论脊髓型颈椎病(CSM)患者体液免疫可能参与CSM发病及影响到CSM患者JOA评分高低及临床症状的轻重。
Objective Through the relationship of the JOA score for the contents of immunoglobulin in the blood serum. And discuss the humoral immunity plays an important role with CSM. Methods The contents of immunoglobulin IgG,IgA,IgM and complement of C3 in the blood serum for the 30 patients with CSM were examined by ratenephelometry;And the 30 patients with CSM were in JOA score,20 normal of the contents of immunoglobulin IgG,IgA,IgM and complement of C3 in the blood serum were examined as control group. Results The contents of immunoglobulin IgG in the serum with CSM was significantly higher than that of the normal control （P〈0.01）;The degree of heavy or midrange （0-12score）and light （13-17score）;The contents of immunoglobulin IgG was significantly difference for the two groups in JOA score basically （P〈0.05）. Conclusion The humoral immunity may be affect high or low of the JOA score and the light or heavy of the clinical syndrome with CSM. And the humoral immunity is an important factor in pathogenesis of the CSM.
出处
《颈腰痛杂志》
2006年第6期448-450,共3页
The Journal of Cervicodynia and Lumbodynia
关键词
颈椎病
脊髓型
体液免疫
cervical spondylotic myelopathy
humoral immunity
