摘要
目的探讨抗β1和α1肾上腺素受体(β1受体和α1受体)自身抗体是否与高血压病合并肾损害有关。方法以合成的β1和α1受体多肽片段为抗原,应用酶联免疫吸附测定(ELISA)技术,检测61例高血压并肾损害患者,60例高血压无肾损患者及40例正常人,血清中抗G-蛋白偶联型β1和α1受体自身抗体。结果高血压病并肾损害组抗β1和α1受体抗体阳性率为62.3%(38/61)和50.8%(31/61),明显高于高血压无肾损害组的13.3%(7/60)和10.0%(6/60)及正常对照组12.5%(5/40)和7.5%(3/40),比较差异有统计学意义(P<0.001)。结论血清抗G-蛋白偶联型β1和α1受体自身抗体可能与高血压合并肾损害发病有关。
Objective To explore the role of the autoantibodies against β1 and α1-adrenergic receptor（ β1-receptor） in the development of hypertension with renal failure. Methods The epitopes of the second extracellular loop of β1 -receptor （ 197 - 222 ） and α1-receptor （192 -218） were synthesized and used respectively to screen sera autoantibodies in patients with hypertension and renal failure （ n =61 ）, hypertension without renal failure （ n = 60） and healthy blood donors （ n = 40, control） by ELISA. Results The positive rates of the autoantibodies against β1 -receptor （62. 3% ）and α1 receptor（50. 8% ） in patients with hypertension with renal failure were higher than those of patients with hypertension without renal failure （ 13.3% and 10. 0% ） （ P 〈0. 001 ）, and those of healthy donors （ 12.5% and 7. 5% ） （ P 〈0. 001 ）. Conclusion The findings suggest that the autoantibodies against β1-receptor and α1-receptor may play important roles in the pathogenesis of the hypertension and renal failure.
出处
《中国医师杂志》
CAS
2006年第11期1446-1448,共3页
Journal of Chinese Physician
