摘要
目的：探讨ｐ５３、ｎｍ２３两种抑癌基因蛋白表达在乳腺癌预后及转移中的价值。方法：应用免疫组化法对８８例人乳腺癌组织进行了ｐ５３、ｎｍ２３蛋白表达研究。结果：ｐ５３阳性表达与肿瘤的组织学分级、淋巴结转移呈显著正相关而与术后生存期呈负相关；而ｎｍ２３则与淋巴结转移呈负相关、与术后生存期呈正相关。结论：ｐ５３及ｎｍ２３蛋白表达可以作为判断乳腺癌患者预后的一个重要参考指标。
Ohjective:To evaluate the value of p53 and nm23 protein expression in prognosis and metastasis of human breast carcinoma. Methods: p53 and nm23 protein expression was observed in paraffin-embeded tissues from 88 primary breast cancers with immunohistochemical methods. Results: p53 positive expression in the breast cancers was associated with higher histological grade,lymph node metastasis and shorter survival of patients. But nm23 protein low expression was actively associated with lymph node metastasis and shorter survival of patients. Conclusion: p53 and nm23 protein expression may be an important indicator of prognosis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1996年第6期564-567,共4页
Academic Journal of Second Military Medical University
关键词
乳腺肿瘤
P53蛋白
NM23蛋白
预后
表达
breast neoplasms
p53 protein
nm23 protein
immunohistochemistry
prognosis
