摘要
目的以口腔脱落细胞学方法探讨食管癌高发区居民口腔黏膜病变和食管黏膜病变的可能关系。方法对河北省磁县食管癌高发区2674名30岁以上成年居民进行口腔脱落细胞学检查。并在双盲条件下对其中335人进行了食管脱落细胞学检查,对比分析其相关关系。结果受检居民中口腔黏膜炎症检出较为普遍,口腔黏膜炎症发生率近30.00%,各年龄组居民发生率随年龄增高而增加,56岁以上人群发生率达到50.00%以上,而30～35岁组只有13.30%。口腔黏膜上皮细胞增生病变的发生率比较低,仅占1.16%。除炎症、增生等病变外,55.90%的当地居民口腔黏膜涂片中可见真菌菌丝。口腔黏膜炎症居民食管黏膜增生病变的发生率明显高于口腔黏膜无炎症者,口腔黏膜炎症与食管黏膜增生病变有明显相关关系(P<0.001)。结论食管癌高发区居民口腔黏膜炎症发生率较高,口腔黏膜炎症与食管黏膜增生病变明显相关。
Objective To evaluate the cytological features of oral mucosa and to explore the putative correlation between the pathological changes in oral and esophageal mucosa of the local residents in the high incidence area of esophageal carcinoma in China. Methods Oral cytological examination was performed in 2674 local residents over 30 years old in the high incidence area of esophageal cancer in Cixian county, Hebei province. Esophageal cytological examination was performed in 335 subjects among the residents with oral cytological examination in a double blind way. The relationship between cytological changes in oral and esophageal mucosa was comparatively analyzed. Results Inflammation was quite frequently seen pathological changes in oral cytological smears. The detection rate of inflammation was as high as 30 % among the subjects examined. The incidence of inflammation increased as the age of subject increases. The detection rates of inflammation in oral smears among subjects over 56 years old were all higher than 50 %, while that in 30 - 35 years group was only 13.30 %. Fungi in oral mucosal cytological smears were found in 55.90 % subjects. Comparative studies showed that the incidence of esophageal epithelial dysplasia in the subjects with oral mucosal inflammatory changes was significantly higher than that in the subjects without oral mucosal inflammatory changes. Conclusion The inflammatory changes of oral mucosa were quite common among the residents in the high incidence area of esophageal carcinoma. The inflammatory changes in oral mucosa were closely related to dysplastic changes in esophageal mucosa.
出处
《肿瘤研究与临床》
CAS
2006年第11期779-781,共3页
Cancer Research and Clinic
基金
科技部"八.五"(85-914-01-01)
"九.五"攻关课题资助项目(96-906-01)
关键词
口腔脱落细胞学方法
食管癌
口腔黏膜病变
食管黏膜病变
Cytological features
Oral mucosa
Pathological changes
Esophageal mucosa
Esophageal carcinoma
