摘要
目的菝葜属百合科植物,为一种常用中药,目前所用的菝葜提取物多为其40%的乙醇提取物,本实验室首创了菝葜的乙酸乙酯提取工艺并对其进行了抑菌活性研究,旨在开发出一种更加符合现代中药要求的新制剂。方法使用液体试管二倍稀释法及小鼠体内抑菌实验,检测菝葜乙酸乙酯提取物在体内外对常见菌的抑制作用。结果菝葜乙酸乙酯提取物可以在体外有效抑制常见菌的增殖,并对染菌小鼠起到显著的保护作用。结论菝葜乙酸乙酯提取物可以在小剂量使用时与菝葜乙醇提取物大剂量使用起到相同的抑菌作用。
Objective Chinese herb Smilax China L. （SCL） is a liliaceous plant which is in common use. Now, the preparations of Smilax are usually extracted by 40% ethanol, we invent a new means to extract the effective material in Smilax and make much research on its action of anti - bacterium. This study was designed to explodre a new preparation. Methods The effect of SCL extract on bacterium proliferation were determined by mouse model and by cultivate bacterium in - vitro. Resuits SCL extract showed proliferation inhibition on several bacterium and the extract of ethylacetate can obtain the same effect on proliferation inhibition of bacterium in the less dosage. Conclusion Ethylacetate extraction of Smilax China L. can restrain familiar bacterium efficiencily with the less dose than the ethanol extraction of Smilax China L.
出处
《医药论坛杂志》
2006年第21期23-25,共3页
Journal of Medical Forum
关键词
菝葜
抑菌
乙酸乙酯
Smilax China L
Anti - bacterium
Ethylacetate （Smilax China L.
