摘要
目的:研究重组人促红细胞生成素(r-HuEPO)对慢性肾功能衰竭患者体内红细胞免疫的影响。方法:45例慢性肾功能不全肾衰竭期(CRF)患者根据治疗情况分为初诊未治疗患者20例(对照组)及规律使用r-HuEPO 1个月以上患者25例(观察组)。应用花环结合率方法测定患者红细胞C3b花环结合率(RBC-C3bRR)及红细胞免疫复合物花环率(RBC-ICRR),分析血红蛋白(Hb)、血肌酐(CRE)的浓度与红细胞C3b花环结合率的相关性。结果:观察组Hb、RBC-C3bRR明显高于对照组(P<0.05);观察组的RBC-ICRR明显低于对照组(P<0.05);Hb浓度与RBC-C3bRR呈正相关(r=0.56,P<0.05);CRE浓度与RBC-C3bRR呈负相关(r=-0.55,P<0.05)。结论:使用r-HuEPO纠正CRF患者贫血后,可以提高CRF患者红细胞膜上C3b受体活性,降低体内CRE水平,提高红细胞膜C3b受体活性,提高CRF患者红细胞免疫功能。
Objective To study the effects of recombinant human erythropoietin （r-HuEPO） on RBC immunity in chronic renal failure （CRF） patients. Methods Forty-five CRF patients were divided into two groups ： 20 patients without r-HuEPO （control group） and 25 patients with r-HuEPO more than one month （experimental group）. The RBC-C3bRR and RBC-ICRR in two groups were counted under microscope and the correlations between HB or CRE and RBC-C3bRR were calculated. Results The concentrationd of Hb, RBC-C3bRR in experimental group were much higher than those in control group （P〈0. 05）. The RBC-ICRR in experimental group was much lower than that in control group （P〈0.05） . There was a positive correlation between HB and RBC-C3bRR （r=0.56, P〈0.05）. There was a negative correlation between CRE and RBC-C3bRR （r=0.55, P〈0.05）.Conclusion r-HuEPO can improve the anaemia in CRF patients, improve the activities of C3b receptors, improve the RBC immunity and depress the CRE concentration.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第6期1071-1073,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅资助课题(9905570)
