期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Rosuvastatin在小鼠大脑中动脉梗死模型中脑保护机制的探讨 被引量：2

下载PDF
导出
摘要 目的探讨HMG-CoA还原酶抑制剂是否可以逆转大脑中动脉梗死导致的脑损及其作用机制。方法检测了正常对照组、90min大脑中动脉梗死模型组、Rosuvaststin组、eNOS基因敲除组的缺血损伤、一氧化氮合酶表达及细胞信号表达的变化。结果Rosuvaststin组可以完全逆转MCAO引起的脑损伤,Westernblot研究表明Rosuvaststin组可以阻止eNOS的降低,降低Erk1/2,使p38水平正常化。结论在小鼠局灶性脑缺血模型中,脑损伤抑制eNOS,激活Erk1/2,抑制P38水平。HMG-CoA还原酶抑制剂Rosuvaststin通过一个依赖于eNOS的机制逆转了MCAO的脑损伤。
作者 王赞 姜宏宇 孟红梅 邢宏义 Angela Fendel
机构地区 吉林大学第一医院 华中科技大学附属协和医院 苏黎世大学附属医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第11期1534-1535,共2页 Chinese Journal of Gerontology
关键词 脑梗死 他汀类药物 神经保护
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献6

  • 1Sironi L,Cimino M,Guerrini U,et al.Treatment with stains after induction of focal ischemia in rats reduces the extent of brain damage Arterioscler Thromb[J].Vasc Bio,2003 ;23:322-7.
  • 2Martin PD.Wawick M J,Dane AL,et al.A double-blind,randomized,incomplete crossover trial to assess the dose proportionality of rosuvastatin in healthy volunteers[J].Clin Ther,2003 ;25:2215-24.
  • 3Kilic E,Dietz G,Hermann DM.Intravenous TAT-BCL-XL is Protective after middle cerebral artery occlusion in mice[J].Ann Neurol,2002; 52:617-22.
  • 4Libby P,Simon DI.Inflammation and thrombosis:the clot thickens[J].Circulation,2001; 103:1718-21.
  • 5Eto M,Kozai T,Cosentino F,et al.statin prevents tissue factor expression in human endothelial cells.Role of Rho/Rho-kinase and Akt pathways[J].Circulation,2002; 105:1756-9.
  • 6曹红,孙长凯,刘丽杰,许晶,陶定波,汪秋艳,侯宇.辛伐他汀或阿托伐他汀对脑梗死患者血清CRP的影响[J].中国老年学杂志,2006,26(3):290-292. 被引量：11

二级参考文献14

  • 1Dziedzic T,Gryz EA,Turaj W,et al.Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients[J].J Mol Neurocci,2004,24:293 -8.
  • 2Silvestri A,Vitale C,Ferretti F,et al.Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke[J].J Am Geriatr Soc,2004 ,52:1586-7.
  • 3Muir KW,Weir CJ,Alwan W,el al.C-reactive protein and outcome after ischemic stroke[J].Stroke,1999 ,30:981-5.
  • 4Hashimoto H,Kitagawa K,Hougaku H,et al.Relationship between C-reactive protein and progression of early carotid atherosclerosis in hypertensive subjects[J].Stroke,2004 ,35:1625-30.
  • 5Patrick L,Uzick M.Cardiovascular disease:C-reactive protein and the inflammatory disease paradigm:HMG-CoA reductase inhibitors,alpha-tocopherol,red yeast rice,and olive oilpolyphenols.A review of the literature[J].Altern Med Rev,2001 ,6:248-71.
  • 6Yasojima K,Schwab C,McGeer EG,et al.Generation of C-reactive protein and complement components in atherosclerotic plaques[J].Am J Pathol,2001, 158:1039-51.
  • 7Tohgi H,Konno S,Takahashi S,et al.Activated coagulation/fibrinolysis system and platelet function in acute thrombotic stroke patients with increased C-reactive protein levels[J].Thrmb Res,2000, 100:373-9.
  • 8Karace I,Ilkay E,Akbulut M,et al.Atorvastat in affects C-reactive protein levels in patients with coronary artery disease[J].Curr Med Res Opin,2003, 19:187-91.
  • 9Laufs U,Gertz K,Dirnagl U,et al.Rosuvastatin,a new HMG-CoA reductase inhibitor,upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice[J].Brain Res,2002,942:23-30.
  • 10Vaughan C J,Delanty N,Basson CT.Statin therapy and stroke prevention[J].Curr Opin Cardiol,2001, 16:219-24.

共引文献10

同被引文献33

  • 1李昌植,葛林宝.超早期电针干预对脑缺血再灌注模型大鼠智能作用的研究[J].吉林中医药,2005,25(2):46-47. 被引量：2
  • 2张成英,苗华,田鹤村,陈前芬.大鼠椎—基底动脉的解剖学观察及其在脑缺血模型中的应用[J].中国临床解剖学杂志,1995,13(1):53-55. 被引量：11
  • 3赵水平,吴军,谭利明,胡治平,肖志杰,聂赛,周宏年,蒋波.他汀类药物对急性脑梗死的抗炎作用[J].中华医学杂志,2005,85(40):2841-2845. 被引量：48
  • 4他汀类药物预防缺血性卒中/短暂性脑缺血发作的专家建议[J].中华内科杂志,2007,46(1):81-83. 被引量：124
  • 5Baigent C, Keech A, Kearney PM. et al. Efficacy and safety of cholesterol- lowering treatment: Prospective meta- analysis of data from 9 0 0 5 6 parlicipams in 1 4 randomised trials of statins[ J ]. Lancet,2005,366:1267 - 1278.
  • 6Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemie stroke or transient attaek:A statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Cardiovascular Radiology and Intervention:The American Academy of Neurology affirms the value of this guideline[J]. Circulation, 2006,113: e409 - e449.
  • 7Plehn JF,Davis BR,Sacks FM,et al. Reduction of stroke incidenee after myocardial infarction with pravastatin:The CholesteroI and Recurrent Events(CARE)study. The Care Investigators[J]. Circulation, 1999,99:216 - 223.
  • 8The Long - Term Intervention with Pravastatin in Ischaemic Disease(LIPID)Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels[J]. N Engl J Med, 1998, 339:1349 - 1357.
  • 9PPP Project Investigators. Design, rational, and baseline characteristics of the Prospective Pravastatin Pooling(PPP)project - a combilled analysis of three largescale randomized trials: Long- term Intervention with Pravastatin in Ischemic Disease(LIPID). Cholesterol and Recurrent Events(CARE), and West of Scotland Coronary Prevention Study(WOSCOPS) [J]. An: J Cardiol, 1995,76 : 899 - 905.
  • 10Byington RP, Davis BR, Plehn JF, et al. Reduction of stroke events with pravastatin: The Prospective Pravastatin Pooling(PPP)Project[J]. Circulation, 2001,103 : 387 - 392.

引证文献2

二级引证文献11

中国老年学杂志
2006年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部