摘要
目的:观察综合康复治疗(抗抑郁药物联合心理干预)对脑梗死后抑郁症状的临床疗效及对血小板5-羟色胺(5-HT)的影响。方法:66例脑梗死后抑郁症状患者随机分为两组,治疗组34例给予药物(帕罗西汀)联合心理干预治疗6周,对照组32例,未接受上述治疗,所有患者在治疗前后均进行Zung量表评分,HAMD评分,ADL评分及血小板5-羟色胺测定。结果:两组Zung量表、HAMD评分治疗后减分明显,ADL评分明显增加且有非常显著性差异(P<0.01),治疗组ADL评分增加更明显,且有非常显著性差异(P<0.01)。伴抑郁症状的脑梗死患者血小板5-HT含量较低,应用联合治疗后,脑梗死患者抑郁症状改善的有效率为70%以上,血小板5-HT含量进一步下降。结论:综合康复治疗对脑梗死后抑郁症状有较好的疗效。血小板5-HT含量可作为早期诊断抑郁症状的实验室筛查指标。
Objective：To discuss the effect of combined therapy of anti-depression medicines and psychotherapy on the rehabilitation of the cerebral infarction patients with depressive symptom. And to observe its effect on platelet serotonin.nethod： Sixty-six patients of cerebral infarction with depressive symptom were randomly divided into two groups. Thirty-four patients in treatment group were treated with paroxetine and psychotherapy for six weeks,32 patients in control group. All patients were measured with Zung,HAMD and ADL score and platelet 5-HT concentration before and after treatment.Result：After treatment,Zung scores and HAMD scores in these two groups were decreased significantly,ADL scores increased significantly（P〈0.01）. Patients in treatment group got statistically significant improvement in ADL scores （P〈0.01）.h was found that cerebral infarction patients with depressive symptoms had a lower level of platelet 5-HT concentration than normal （P〈0.01）. After six weeks of combined treatment, symptoms of depression were significantly better than before （P〈0.01）.The level of platelet 5-HT concentration after treatment was lower than before.Conclusion：It is suggested that combined rehabilitation treatment was an available therapy in cerebral infarction patients with depressive symptom. Platelet 5-HT concentration would be used as an early screening mark of patients with depressive symptom.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2006年第11期1005-1007,共3页
Chinese Journal of Rehabilitation Medicine
关键词
脑梗死
抑郁症状
5-羟色胺
心理治疗
帕罗西汀
cerebral infarction
depressive symptom
serotonin
psychotherapy
paroxetine
