摘要
目的观察微波热凝与慢咽合剂联合治疗对慢性肥厚性咽炎患者咽黏膜病理组织学的影响。方法慢性肥厚性咽炎患者120例,随机分为两组,治疗组62例,先予微波热凝治疗,然后加服慢咽合剂;对照组58例,仅采用微波热凝治疗。所有患者均分别在治疗前及治疗结束后2周取同一部位咽黏膜组织作病理组织学检查,并评定临床疗效。结果治疗组治疗后咽黏膜组织的炎性细胞浸润程度明显轻于对照组,伴纤维组织增生,较少出现淋巴组织增生或淋巴滤泡形成,而对照组常伴有淋巴组织增生及淋巴滤泡形成。治疗组疗效明显优于对照组(P=0.001),复发率明显低于对照组(P=0.005)。结论微波热凝与慢咽合剂联合治疗慢性肥厚性咽炎可明显减轻咽黏膜的炎性细胞浸润程度,临床疗效显著。
Objective To investigate the effect of microwave coagulation therapy combined with Manyan Oral Mixture （MYOM） on the pathohistological changes in pharyngeal mucosa of patients with chronic hypertrophic pharyngitis. Methods One hundred and twenty cases with hypertrophic pharyngitis were included in this study and they were randomly divided into 2 groups, with 62 cases in treating group （TG） treated by the combined therapy with microwave coagulation at first and followed by MYOM orally taken for 14 days then and 58 in controlling one （CG） treated only by microwave coagulation therapy. Pathohistological assays on pharyngeal mucosa were carried out before and after the therapy respectively, with the evaluation on the therapeutic effect and pathohistological changes made by the end of therapy. Results The degree of inflammatory cell infiltration in pharyngeal mucosa was significantly milder in TG than that in CG, only companied by fibrous tissue proliferation with few lymphatic hyperplasia or lymphoid follicle formation in TG, which was in contrast with that of CG showing more obvious lymphatic hyperplasia and lymphatic follicle formation. As a result of this, the therapeutic effect of TG was significantly superior to that of CG （P = 0. 001） and the reoccurring rate was significantly lower in TG than in CG （P = 0. 005）. Conclusions The therapeutic effect of microwave coagulation therapy combined with MYOM on chronic hypertrophic pharyngitis is very significant and it may be brought about through reducing the degree of inflammatory cell infiltration in pharyngeal mucosa.
出处
《中国中西医结合耳鼻咽喉科杂志》
2006年第6期372-375,I0001,共5页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
广东省中医药局立项科研课题(编号1050012)
广东省佛山市医学科学技术研究计划项目(编号2004124)
关键词
慢性肥厚性咽炎
微波热凝
慢咽合剂
病理组织学
Chronic hypertrophic pharyngitis
Microwave coagulation
Manyan Oral Mixture
Pathohistology
