摘要
本文报道1991～1995年,对新疆伽师县夏普桃勒乡妇女子宫颈癌的普查结果,普查率为 76.4%,子宫颈癌初查患病率为459/10万.子宫颈癌发生与早婚、多胎产有显著相关性.应用PCR技术对普查检出的13例和该乡邻近地区同期住院的28例子宫颈浸润癌患者标本行HPV16、18型检测,阳性率分别为84.61%和82.14%,其中HPV16型占75.6%(31/41).81例子宫颈炎阳性率为 22.22%,与浸润癌检出率比较有极显著性差异(P<0.01).提示该地区子宫颈癌发生可能与HPV16、18型感染有关,特别与HPV16型感染关系更为密切.
The results of a mass servey on cervical carcinoma (CC) in Xaptul Township, Jashi County,Xinjiang in 1991-1995 were reported. The survey rate was 76. 4% and the prevalence of first survey of CC was 459/100 000. There were significant correlation between CC with early marriage and plural birth. Thirteen cases with invasive cervical carcinoma (ICC) from this survey and 28 admitted cases with ICC from the same county were tested for HPVl6、18 with PCR technique. The positive rate of HPV16、18 were 84.6% and 82. 14% respectively, and the HPV16 positive cases accounted for 75. 6%(31/41). While the positive rate of HPV16、18 in 81 cases with cervicitis was 22. 22%(P<0. 01) .It suggested that the prevalence of ICC in this area might be correlated with the infection of HPV16、18 especially that of HPV16.
基金
新疆维吾尔自治区卫生厅课题
关键词
宫颈癌
人乳头瘤病毒
聚合酶链反应
carcinoma of the cervix
human papilloma virus (HPV)
PCR
