摘要
目的探讨慢性肾衰竭维持性血液透析患者血清脂蛋白(α)和C-反应蛋白的变化及其临床意义。方法慢性肾衰竭维持性血液透析患者43例和健康对照组34例,均测定血脂,包括血清脂蛋白(α)[Lp(α)]、C-反应蛋白(CRP);并将43例慢性肾衰竭维持性血液透析患者分为合并冠心病组(21例)和非合并冠心病组(22例),并分析Lp(α)、CRP和血肌酐(Scr)3项指标在2组中的变化。结果慢性肾衰竭维持性血液透析组Lp(α)和CRP均较健康对照组明显升高(P<0.01),慢性肾衰竭维持性血液透析合并冠心病组Lp(α)和CRP较非合并冠心病组明显升高(P<0.01)。结论慢性肾衰竭维持性血液透析患者Lp(α)和CRP明显高于正常人,说明血液透析虽是慢性肾衰竭替代治疗的有效方法,却不能降低LP(α)及CRP的水平。Lp(α)和CRP的升高可以导致其合并冠心病几率增加,慢性肾衰竭维持性血液透析患者合并冠心病与Lp(α)和CRP的升高密切相关。
Objective To study the changes of lipoprotein-a （ Lp （ α ） ） and C-reactive protein （ CRP ） in chronic renal failure patients with maintenance hemodialysis and their clinical significance. Methods Scrum lipid including Lipoprotein-α and C-reactive protein in 43 chronic renal failure patients with＇maintenance hemodialysis and 34 healthy subjects were determined. 43 patients were divided into the patients complicated with coronary heart diseases （ group A, n = 21 ） and without coronary heart disease （ group B, n = 22 ） , whose Lp （ α ） , CRP and well as Scr were determined. Results Lp（ α ） and CRP levels in chronic renal failure patients were significantly higher than those of healthy controls（ P 〈 0.01）. In chronic renal failure patients,the Lp（ α） and CRP levels were significantly higher in group A than in group B （P 〈 0.01 ）. Conclusion The higher levels of Lp（ α） and CRP indicate that hemodialysis can not decrease the level of Lp（α） and CRP although it is the effective way to treat chronic renal failurc. The increase of Lp（α） and CRP may cause the increased risk of coronary heart failure,so it is closely correlated with coronary heart failure in chronic patients with maintenance hemodialysis.
出处
《中国综合临床》
北大核心
2006年第12期1087-1088,共2页
Clinical Medicine of China
