摘要
目的：了解我院药品不良反应（ADR）的发生特点，促进临床合理用药。方法：对我院2004年-2005年间上报的138例ADR报告进行回顾性分析。结果：与合并用药有关的ADR占总例数的44．2％（61例），以静脉给药方式为主，共涉及53神药品，与抗感染用药有关的ADR最为多见，占总倒数的55．1％（涉及15种抗感染药）。ADR发生频率最高的4种药品是左氧氟沙星、加替沙星、头孢噻肟钠和头孢曲松钠；ADR表现以皮肤损伤最为常见，其次是消化系统损害等；较严重的ADR有1倒。结论：应加强专业人员的业务和素质培养，开展全方位的ADR监测工作，以指导临床合理用药。
OBJECTIVE： To investigate the features of adverse drug reactions （ADRs） in our hospital so as to promote rational drug use in the clinic. METHODS： A total of 138 ADR reports collected during 2004 - 2005 in our hospital were analyzed retrospectively. RESULTS： Of the total ADR cases, 44.2% （61 cases） were induced by combined use of drugs, chiefly through Ⅳ. Altogether 53 drug varieties involved ADRs. Anti-infective agents （ 15 varieties are involved in ADRs） showing the highest proportion of ADRs, accounting for 55.1% of the total. The first 4 drugs that involved high incidences of ADRs were levofloxacin, gatifloxacim, cefotaxime sodium and ceftriaxone sodium, respectively. ADRs manifested dominantly by skin damage, followed by gastro- intestinal damage and etc. There was 1 severe ADR case. CONCLUSION The cultivation of professional ability and quality of professional staff should be strengthened and an omnibearing ADR monitoring work should be carried out so as to promote rational drug use in the clinic.
出处
《中国医院用药评价与分析》
2006年第5期307-309,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
报告
分析
adverse drug reactions （ADRs）
reports
analysis
