摘要
目的探讨术前膀胱灌注resiniferatoxin(RTX)预防前列腺术后膀胱痉挛的效果。方法按住院顺序选择良性前列腺增生(BPH)拟行耻骨上前列腺切除术患者20例,随机分为对照组和观察组,每组10例。观察组患者术前3 d向膀胱灌注RTX原液4 ml+生理盐水(NS)100 ml,停留时间0.5 h;对照组患者术前3 d向膀胱灌注NS 104 ml,停留时间0.5 h。所有患者均在腰硬联合麻下行耻骨上前列腺切除术。结果观察组与对照组患者术后膀胱痉挛发生率分别为20%和80%,冲洗液转清时间为(2.8±1.7)d和(5.2±1.0)d,造瘘管留置时间为(4.0±1.6)d和(5.8±1.1)d,导尿管留置时间为(9.3±1.3)d和(11.8±1.1)d,疼痛视觉模拟评分为(2.3±1.3)分和(4.6±1.1)分,差异均有显著性(P<0.05)。观察组与对照组患者拔除导尿管和膀胱造瘘管1,2,4周后的国际前列腺症状评分分别为(11.1±3.3)分和(16.0±3.0)分,(9.5±1.4)分和(12.7±3.2)分,(8.4±1.6)分和(11.3±2.7)分,差异均有显著性(P<0.05)。观察组与对照组患者拔除导尿管和膀胱造瘘管4周后的生活质量评分分别为(1.6±0.5)分和(2.8±0.9)分,差异有显著性(P<0.05)。结论术前膀胱灌注RTX能降低前列腺术后膀胱痉挛的发生率和严重程度。
Objective To evaluate the effects of intravesical instillations of resiniferatoxin（RTX） preoperatively for prevention of cystospasm after suprapubic prostatectomy.Methods From July,2003 to October,2005,20 patients with benign prostatic hyperplasia（BPH） scheduled for suprapubic prostatectomy were randomly divided into two groups, the control group and freatment group. Each group consisted of 10 patients. 4 ml of RTX plus 100 ml of saline was instilled into the bladder and stayed for 30 minutes 3 days before operation in treatment group. 104 ml of saline instead of RTX was instilled in the control group. Suprapubic prostactomies were performecl. Results After the operation, the incidence of cystospam was 20% and 80 %, the time that the peffusion liquid needed to become clear was 2.8 ± 1.7 and 5.2 ± 1.0 days, the time the suprapubic tube lasted was 4.0 ± 1.6 and 5.8 ± 1.1 days, the time for which the catheter had been indwelled was 9.3 ± 1.3 and 11.8 ± 1.1 days, the visual analog scores of pain were 2.3 ± 1.3 and 4.6 ± 1.1, respectively, in the treatment group and control group（ P 〈 0.05）. The international prostatic symptoms scores at the first week, second week and forth week after removal of the catheter and suprapubic tube were 11.1 ± 3.3 and 16.0 ± 3.0, 9.5 ± 1.4 and 12.7 ± 3.2, 8.4 ± 1.6 and 11.3 ± 2.7,separately, in the treatment group and control group（ P 〈 0.05）. The quality of life was 1.6 ± 0.5 and 2.8 ± 0.9 in the subject and control groups, respectively（ also P 〈 0.05）. Conclusion The incidence and severity of post - operative cystospasm secondary to prostactomy can be redued by intravesical instillations of RTX before operation.
出处
《广东医学》
CAS
CSCD
北大核心
2006年第12期1813-1814,共2页
Guangdong Medical Journal
基金
广东省广州市医药卫生科技项目(编号:穗卫科2004-21-4)
