摘要
以γ-丁内酯为原料,经酯化和氯化得到中间体γ-氯丁酸甲酯。在无水碳酸钾存在下,N,N-二甲基甲酰胺(DMF)为溶剂,由γ-氯丁酸甲酯和4-苯氧基苯酚反应,合成了4-(4-苯氧基苯氧基)丁酸甲酯。着重研究了反应温度、反应时间、投料摩尔比对4-(4-苯氧基苯氧基)丁酸甲酯收率的影响。从而确定了合成工艺条件为。在此条件下,4-(4-苯氧基苯氧基)丁酸甲酯的收率达82%以上。通过IR1、H NMR及元素分析等对产物进行了表征。
The methyl - 4 - （4 - phenoxy） phenoxybutyrate is synthesized from 4 - phenoxyphenol and methyl- γ-chorobutyrate which is obtained by reacting γ- butyrolactone in DMF the presence of anhydrous sodium carbonate as catalyst. The effects of reaction temperature, reaction time, molar ratio of the reactants on the yield of the are studied. The reaction temperature is 95 ℃, the reaction time is 4.0 hr, and the molar ratio of 4 - phenoxyphenol to methyl - γ- chorobutyrate is 1 ： 1.15. The yield of methyl - 4 - （4 - phenoxy） phenoxybutyrate at these conditions is up to 82 %. The product is characterized by the IR spectrum, ^1H NMR spectrum and element analysis.
出处
《上海应用技术学院学报（自然科学版）》
2006年第3期177-179,187,共4页
Journal of Shanghai Institute of Technology: Natural Science
基金
上海市教育委员会科研基金资助项目(050Z13)
