摘要
采用醋酸氢化考的松致肾虚模型和大黄致脾虚模型探讨两者甲状腺轴功能的改变，结果显示，肾虚造型使Ｔ３、Ｔ４分泌减少（Ｐ＜０．０１），ｒＴ３也明显下降（Ｐ＜０．０５），推测Ｔ４向ｒＴ３转化减少，尽管如此，ＴＳＨ无反馈性升高，说明其甲状腺轴已有明显的受抑。脾虚造型组Ｔ３（Ｐ＜０．０５）、Ｔ４（Ｐ＜０．０１）也有所降低，但幅度不如肾虚造型组大（Ｐ＜０．０５），ｒＴ３保持正常，而ＴＳＨ反馈性升高，显示甲状腺轴功能尚未完全受损。肾虚造型后补肾治疗以及脾虚造型后补脾治疗均能使上述改变恢复（Ｐ＜０．０５）。
The kidney-deficiency and spleen-deficiency model mice wese established by hydrocortisone acetate and rhubarb (大黄)respectively,and their thyroid axis functions were compared,The results showsd that secretions of T 3,T 4 and rT 3 in kidney-deficiency were significantly reduced(T 3 and T 4,P<0.01;rT 3,P<0.05),but the feedback elevation of TSH did not occur, indicating that transformations of T 4 to rT 3 were decreased and the thyroid axis functions were inhibited significantly.In spleen-deficiency,T 3 and T 4 were also reduced (P<0.05 and P<0.01 respectively),but their ranges of reduction were not so great as those of the kidney-deficiency (P<0.05) .rT 3 kept normal and the feedback elevatin of TSH occurred,indicating that the thyroid axis functions were not restrained. After treatment of kidney-reinforcing and spleen-reinforcing drugs all above changes recovered.
出处
《广州中医药大学学报》
CAS
1996年第2期31-33,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
肾虚
中医药疗法
脾虚
补气药
KIDNEY ASTHENIA/TCM ther. SPLEEN ASTHENIA/TCM ther. KIDNEY-REINFORCING DRUGS/ther. QI-REINFORCING AGENTS /ther.use THYROID FUNCTION TESTS DISEASE MODELS,ANIMAL MICE
