摘要
目的观察两种机械通气方式对海水淹溺肺水肿(pulmonary edema after seawater drowning,PE-SWD)兔的救治作用。方法应用常规机械通气(CMV)和高频喷射通气(HFJV)对PE- SWD兔进行分组救治,在不同时间点观察血气分析、呼吸动力学、血液动力学、肺损伤指标,并进行病理学检查和观察存活时间,从而观察两种机械通气方式治疗PE—SWD的效果。结果两种通气方式治疗后,血氧分压(PaO2)、血氧饱和度(SO2)、二氧化碳分压(PaCO2)均较未治疗组有明显改善(P<0．01),呼吸动力学、血液动力学异常得到一定程度纠正,TNF-α、肺泡灌洗液中性粒细胞计数等部分肺损伤指标也显示机械通气治疗后肺损伤程度减轻。两种通气方式之间比较显示,CMV较HFJV治疗能更好地改善PE-SWD的低氧情况。结论CMV和HFJV治疗PE-SWD低氧血症均取得满意效果,并减轻了肺损伤的程度。
Objective To observe the therapeutical effect of conventional mechanical ventilation （CMV） and high frequency jet ventilation （HFJV） on pulmonary edema after seawater drowning in rabbits. Methods Twenty-eight pulmonary edema New Zealand rabbit models were randomly assigned to received CMV and HFJV treatment. Blood gas analysis, pneumodynamic, hemodynamics status and tumor necrosis factor （TNF-α） extracted from serum were monitored at various time points. After 3 hours＇ventilation, 7 rabbits of each group were killed to gain lung tissues for pathology examination and lung lavage fluid was analyzed for leukocyte count. Results PaO2 and SO2 were significantly increased after the use of ventilation in pulmonary edema rabbit models（ P 〈 0.01） ,especially in CMV treatment group. Pneumodynamic and hemodynamic status were ameliorated. The results of TNF-α monitor and leukocyte count showed that lung injury were relieved. CMV treatment had better efficiency in ameliorating hypoxemia, compared with HFJV treatment. Conclusions Our study showed CMV and HFJV could significantly improve hypoxemia in PE-SWD rabbits, and to some extent, relieve lung injury.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2006年第4期204-208,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
机械通气
肺水肿
海水
Mechanical ventilation
Pulmonary edema
Seawater
