摘要
目的探讨凋亡抑制基因survivin在食管鳞癌组织中的表达及其与环氧合酶-2(COX-2)的相关性。方法采用免疫组化S-P法检测68例食管癌组织及15例正常食管黏膜组织中survivin蛋白和COX-2蛋白的阳性表达率。结果survivin蛋白在15例正常食管黏膜中呈阴性表达,而68例食管癌组织中45例阳性,占66.1%,差异有显著性。COX-2蛋白在食管癌组织中的阳性表达率为79.4%(54/68)。survivin蛋白阳性率与年龄、性别、原发部位无关,而与分化程度、有无淋巴结转移相关,并与COX-2蛋白阳性表达呈正相关。(Pearson列联系数为0.434)。结论survivin蛋白在食管癌的发生发展中起重要作用,survivin蛋白与COX-2蛋白密切相关,2者可能存在共同的激活机制,构成肿瘤细胞凋亡的多种途径。
Objective To detect the expression of inhibitor gene of apoptosis, survivin, in esopheagal squamous carcinoma（ESC） and analysis its relationship with COX-2. Methods The expression of survivin and COX-2 in 68 eases in ESC and 15 no real esophageal tissues were detected by immunohistochemistry（ the method of streptoridin-peroxidase,SP）. Results In contrast to negative expression in no real esophageal mucosa,survivin expressed in 45 of 68 eases of ESC samples. COX-2 protein expressed in 54 of 68（79.4% ）. There were no relationship among survivin expression and age, sex, and tumor location. There were relationship between survivin gene expression and degree of differentiation,lymph node me- tastasis. The expression of survivin was positively correlated with that of COX-2. Conclusion The specific up regulation of survivin in ESC suggests that survivin may play an important role in the process of carcinoma genesis, h was speculated that there may be a common transcription meehnism which constructed multiple pathways.
出处
《临床消化病杂志》
2006年第6期353-355,共3页
Chinese Journal of Clinical Gastroenterology
