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重症肺炎患者血清和肺泡灌洗液IL-6和IL-10的动态变化及临床意义 被引量:10

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摘要 目的探讨促炎细胞因子白细胞介素-6(IL-6)和抑炎细胞因子白细胞介素-10(IL-10),在重症肺炎患者血清和肺泡灌洗液(BALF)中的动态变化及与预后关系。方法据患者综合治疗10d后临床转归的不同,将患者分为好转组和恶化组。用放免法动态检测两组患者第1,4,7天血清和BALF中IL-6、IL-10的水平.观察它们在这两种不同预后患者中的变化特点。结果两组患者血清和BALF中IL-6均呈现下降趋势,但尚未出现显著性差异。好转组患者血清和BALF中IL-10也呈下降趋势;但恶化组患者IL-10则呈明显上升趋势,第7天IL-10水平明显高于第1、4天(P值均<0.05)。另外,恶化较好转组患者血清和BALF中IL-10水平明显增高,其中第4、7天出现显著性差异(血清:8.51±5.32 vs 3.89±2.81;7.37±5.99 vs 2.47±2.99,P值均<0.05。BALF:14.71±7.82 vs 1.92±2.86:16.82±5.25 vs 0.14±0.19.P值均<0.05)。结论动态检测血清和BALF中IL-10水平,可反映重症肺炎患者的预后。
出处 《中国急救医学》 CAS CSCD 北大核心 2006年第12期950-951,共2页 Chinese Journal of Critical Care Medicine
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