摘要
在Wistar新生大鼠离体培养胰岛细胞中定量观察了IL-1β对胰岛素分泌的抑制作用以及牛磺酸的反转效应。实验结果表明:①IL-1β(5~20U/ml)可抑制胰岛β细胞的分泌功能,表现为胰岛素的基础分泌和葡萄糖刺激时的分泌量均明显减少。②经IL-1β处理的胰岛细胞加入牛磺酸共同孵育后,可见胰岛素的基础分泌量和糖刺激时的分泌量均显著增加,表明牛磺酸能反转IL-1β的抑制作用,并且这种反转效应有量效和时效关系。
The effect of taurine on IL-1βinduced inhibition of insulin release was investigated with cultured neonatal rat pancreatic islet cells.The results indicated that:①Insulin release, both the basal and glucose-stimulated,could be significantly inhibited by addition of IL-1β(5~20U/ml).②The inhibitory effect of IL-1β on insulin release could be reversed by taurine and this effect was directly related to the dose and action time of taurine.
出处
《中国糖尿病杂志》
CAS
CSCD
1996年第4期225-227,共3页
Chinese Journal of Diabetes