摘要
沙利度胺治疗实体肿瘤的作用机制是多方面的,主要是抑制实体肿瘤新生血管生成,协同激活T淋巴细胞,抑制增殖,诱导凋亡。目前许多评估沙利度胺治疗晚期消化道肿瘤的二期临床研究已经肯定沙利度胺在治疗消化道肿瘤中的作用。此文着重介绍沙利度胺在治疗消化道肿瘤中的作用机制,临床研究进展,以及今后的研究发展方向。
The mechanism of action of thalidomide is complex and it probably includes different molecular target. First, thalidomide can inhibit angiogenesis of the solid tumor. Then thalidomide can co-stimulatory actions on primary human T-cells enhance the antitumor activity. At last the thalidomide can prevent the tumor cell proliferating and induce the tumor cell into apoptosis. Current clinical trails in phase Ⅱ have confirmed the action of thalidomide in digestive tumor. This article introduce the mechanism of thalidomide in treating digestive tumor, the new finding in the current clinical trails, and what we can do about thalidomide in future.
出处
《国际消化病杂志》
CAS
2006年第6期387-389,共3页
International Journal of Digestive Diseases
