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羟乙基淀粉130/0.4的药理特性和安全性研究 被引量:24

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摘要 羟乙基淀粉130/0.4(万汶)作为一种新型的血浆代用品被国外广泛应用于临床,近一年来开始逐步应用于国内患者,笔者通过回顾近5年来国外文献资料,对万汶的理化特性,及其对血流动力学、肾功能、凝血功能、细胞内皮功能及组织氧供的影响进行分析,综合论述万汶的药理特性及临床应用的安全性和有效性。
出处 《四川医学》 CAS 2006年第12期1231-1233,共3页 Sichuan Medical Journal
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参考文献14

  • 1Baron JF.A new hydroxyethyl starch:HES 130/0.4,voluven[J].Transfusion Alternatives in Transfusion Medicline,2000,2(2):13~21
  • 2Waitzinger J,Bepperling F,Pabst G,et al.Effect of a new HES specification (6% HES130/0.4)on blood and plasma volumes after bleeding in 12 healthy male volunteers[J].Clin Drug Invest,1999,17(2):119~125
  • 3Waitzinger J,Bepperling F,pabst G,et al.Phannacokinetics and tolerability of a new hydroxyethyl starch(HES) specification(HES130/0.4) specification(HES 130/0.4) after single dose infusion of 6 % or 10 % solution in healthy volunteers[J].Clin Drug invest,1998,16(2):151~160
  • 4Ickx BE,Bepperling F,Melot C,et al.Plasma substitution effects of a new hydroxyethyl starch HES 130/0.4 compared with HES 200/0.5 during and after extended acute normovolaemic haemodilution[J].Br J Anesth,2003,91(2):196~202
  • 5langeron O,Doelberg M,Ang ET,et al.Voluven,a lower substituted novel hydroxyethyl starch (HES130/0.4)caude fewer effects on coagulation in major orthopedic surgery than HES200/0.5[J].Anesth Analg,2001,92(4):855~862
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  • 7Standl T,Burmeister MA,Schroeder F,et al.Hydroxyethyl starch (HES)130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES200/0.5 in volunteers undergoing acute normovolemic hemodilution[J].Anesth Analg,2003,96(4):936~943
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二级参考文献2

  • 1J. Treib,J.-F. Baron,M. T. Grauer,R. G. Strauss. An international view of hydroxyethyl starches[J] 1999,Intensive Care Medicine(3):258~268
  • 2Professor Dr. med. K. F. W. Messmer M.D.. The use of plasma substitutes with special attention to their side effects[J] 1987,World Journal of Surgery(1):69~74

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引证文献24

二级引证文献108

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