摘要
目的:探讨肺结核合并支气管内膜结核的治疗的合理性。方法:对164例初治涂阳肺结核经纤支镜检查确诊的支气管内膜结核病人,在异烟肼(H)、利福平(R)、吡嗪酰胺(Z)、乙胺丁醇(E)化疗至少2mon的基础上同时每周一次行纤支镜局部治疗,直至痰菌转阴。对治疗2mon以上痰菌未转阴者继续强化治疗直至痰菌转阴。以痰菌转阴为界用HR巩固治疗3mon。结果:满疗程痰菌转阴率达98.78%,平均化疗期达4.52mon。经2年随访,细菌学复发率为1.23%。结论:初治涂阳肺结核合并支气管内膜结核辅以纤支镜局部治疗4.52mon可取得与2HRZE/4HR相同的远期痰菌转阴率。提示:肺结核合并支气管内膜结核采用新方法治疗即可缩短疗程,节约经费,减少副作用,疗效可靠。
Objective： To search for the rationality of the treatment of pulmonary tuberculosis combined with endobronchial tuberculosis.Method： To the 164 patients who had been diagnosed with fiberopic bronchoscope as Endobroncbial Tuberculosis,we basically treat them with isoniazidum（H）,pifampin（R）,pyrazinamidium（Z）,ethambutol（E） for 2 months,meanwhile,we use fiberopic bronchoscope weekly to cure the pathological area until the smear turns negative. To the patients whose smears are still positive,although being given a 2 months therapy,we will intensify the therapy until it turns negative.In other case, we strengthen the treatment for 3 months on the boundary result.This phase includes a tow month intensive period.Results： The rate of patients whose smears turned negative reaches 98.78%,and the average course of treatment took 4.52 months,Through a followed visit of the patients in the two years period ,the rate of recurrence in bacteriology reached 1,23%, Conclusion： The treatment of fiberopic bronchoscope for 4.52 months has gained the same effect compared with the 2 HRZE/4HR therapy.Indication The new treatment for Pulmonary Tuberculosis combined with Endobronchial Tuberculosis can shorten the time required,economize the expenses,reduce the side-effect,safe and reliable,
出处
《抗感染药学》
2006年第4期158-159,共2页
Anti-infection Pharmacy
关键词
肺结核
支气管内膜结核
个体化治疗
Pulmonary tuberculosis
Endobronchial tuberculosis
individual care
