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甲状腺癌再分化治疗的研究现状 被引量：1

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摘要 甲状腺癌虽仅占人类全部恶性肿瘤的1％，但在内分泌系统中是最常见的一类恶性肿瘤。目前甲状腺癌的人群发病率为1／20万～1／30万，2003年美国新增甲状腺癌患者约22000例，其中男性约5700例，女性约16300例。甲状腺癌通常有4种病理类型：乳头状癌（占70％～75％）、滤泡状癌（占15％～20％）、未分化癌（占3％～5％）、髓样癌（占1％～3％）。前2种源于滤泡上皮细胞，总体分化良好，称为分化型甲状腺癌（DTC）。多数DTC恶性程度不高，病程缓慢，即便出现局部转移，也可通过手术、^131Ⅰ内照射、甲状腺激素替代抑制治疗控制病情甚至痊愈。未分化癌恶性程度较高，预后较差。髓样癌源于滤泡旁C细胞，多数病例的临床进展较快，手术是目前主要治疗手段。
作者 罗琼 陆汉魁
机构地区 上海交通大学附属第六人民医院核医学科
出处 《中华核医学杂志》 CAS CSCD 北大核心 2006年第6期382-384,共3页 Chinese Journal of Nuclear Medicine
关键词 分化型甲状腺癌 分化治疗 滤泡状癌 恶性肿瘤 未分化癌 恶性程度 内分泌系统 乳头状癌
分类号 R736.1 [医药卫生—肿瘤]
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参考文献26

  • 1Jemal A,Murray T,Samuels A,et al.Cancer statistics,2003.CA Cancer J Clin,2003,53:5-26.
  • 2Hundahl SA,Fleming ID,Fremgen AM,et al.A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the US,1985-1995.Cancer,1998,83:2638-2648.
  • 3Chan HM,Krstic-Demonacos M,Smith J,et al.Acetylation control of the retinoblastoma tumour-suppressor protein.Nat Cell Biol,2001,3:667-674.
  • 4陈立波,朱瑞森.NIS在肿瘤核素基因显像与治疗中的应用研究[J].国外医学（放射医学核医学分册）,2005,29(2):70-73. 被引量：2
  • 5张一帆,李彪.钠/碘同向转运体在甲状腺癌^(131)I治疗中的应用[J].国外医学（放射医学核医学分册）,2004,28(6):249-252. 被引量：1
  • 6Haugen BR,Larson LL,Pugazhenthi U,et al.Retinoic acid and retinoid carcinoma cell lines and predict response to treatment with retinoids.J Clin Endocrinol Metab,2004,89:272-280.
  • 7Schmutzler C,Winzer R,Meissner-Weigl J,et al.Retinoic acid increases sodium/iodide symporter mRNA leverls in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells.Biochem Biophys Res Commun,1997,240:832-838.
  • 8匡安仁.维甲酸诱导分化在分化型甲癌治疗中的应用.见:蒋宁一,主编.肿瘤核医学.北京:人民卫生出版社,2002.294-297.
  • 9Simon D,Korber C,Krausch M,et al.Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer:final results of a pilot study.Eur J Nucl Med,2002,29:775-782.
  • 10Grunwald F,Menzel C,Bender H,et al.Redifferentiation therapyinduced radioiodine uptake in thyroid cancer.J Nucl Med,1998,39:1903-1906.

二级参考文献60

  • 1Venkataraman GM, Yatin M, Marcinek R, et al. Restoration of iodide uptake in dedifferentiated thyroid carcinoma: Relationship to human Na+/I-symporter gene methylation status[J]. J Clin Endocrinol Metab, 1999, 84(7): 2449-2457.
  • 2Kitazono M, Robey R, Zhan Z, et al. Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+) / I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells[J]. J Clin End
  • 3Zarnegar R, Brunaud L, Kanauchi H, et al. Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor[J]. Surgery,2002, 132(6): 984-990.
  • 4Smit JW, Schroder-van der Elst JP, Karperien M, et al. Reestablishment of vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line[J]. Thyroid, 2000, 10(11): 939-943.
  • 5Haugen BR, Larson LL, Pugazhenthi U, et al. Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids[J]. J Clin Endocrinol Metab, 2004, 89(1): 2
  • 6Smit JW, Schroder-Van der Elst JP, Karperien M, et al. Iodide kinetics and experimental 131I therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line[J]. J Clin Endocrinol Metab, 2002, 87(3): 124
  • 7Huang M, Batra RK, Kogai T, et al. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer [J]. Cancer Gene Ther, 2001, 8(8): 612-618.
  • 8Castro MR, Bergert ER, Goellner JR, et al. Immunohistochemical analysis of sodium iodide symporter expression in metastatic differentiated thyroid cancer: correlation with radioiodine uptake[J]. J Clin Endocrinol Metab, 2001, 86(11): 5627-5632.
  • 9Schmutzler C, Winzer R, Meissner-Weigl J, et al. Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells[J]. Biochem Biophy
  • 10Arturi F, Russo D, Schlumberger M, et al. Iodide symporter gene expression in human thyroid tumors[J]. J Clin Endocrinol Metab, 1998,83(7): 2493-2496.

共引文献2

同被引文献10

  • 1王生余,张旭辉,于晓妉.新型抗肿瘤药物组蛋白去乙酰化酶抑制剂[J].国际肿瘤学杂志,2006,33(6):404-406. 被引量：12
  • 2Kogai T,Taki K,Brent GA.Enhancement of sodium/iodide symporter in thyroid and breast cancer.Endocr Relat Cancer,2006,13:797-826.
  • 3Marks PA,Rifkind RA,Pdchon VM,et al.Histone deacetylases and cancer:causes and therapies.Nat Bey Cancer,2001,1:194-202.
  • 4Kitazono M,Robey Rob,Zhan ZR,et al.Low cencentrations of the histone deacetylase inhibitor,depsipeptide(FR901228),increase expression of the Na^+/I^-symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells.J Clin Endocrinol Metab,2001,86:3430-3435.
  • 5Bolden JE,Peart MJ,Johnstone RW.Anticancer activities of histone deacetylase inhibitors.Nat Bey Drug Discov,2006,5:769-784.
  • 6Shen WT,Wong TS,Chung WY,et al.Valpreic acid inhibits growth,induces apoptesis,and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells.Surgery,2005,138:979-985.
  • 7Zarnegar R,Brunaud L,Kanauchi H,et al.Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichustatin A,a histone deacetylase inhibitor.Surgery,2002,132:984-990.
  • 8Yoon JK,Park BN,Paik jY,et al.Effects of thcophy lline on radioiodide uptake in MCF-7 breast cancer and NIS gene-trans duced SNU-C5 colon cancer cells.Cancer Biother Radiophann,2009,24:201-208.
  • 9Fang JY.Histone descetylase inhibitors,anticancerous mechanism and therapy for gastrointestinal cancers.Gestrcenterol Hepatol,2005,20:988-994.
  • 10Tumber T,Collins L,Petersen K,et al.The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit tumour cell growth in vitro and in vivo.Proc Am Assoc Cancer Res,2005,46:1202-1203.

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中华核医学杂志
2006年 第6期

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