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子宫内膜间质瘤中雄激素受体(AR)表达的实验研究

Study on Expression of Androgen Receptors in Endometrial Stromal Neoplasms
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摘要 目的探讨子宫内膜间质肉瘤中是否表达雄激素受体(AR)。方法研究20例肿瘤标本,其中3例为子宫内膜间质结节(ESN)、14例为低度恶性子宫内膜间质肉瘤(ESS)和3例高度恶性子宫内膜间质肉瘤(UES)、用免疫组化法测定经甲醛溶液固定、石蜡包埋的肿瘤标本。结果雌激素(ER)和孕激素(PR)阳性免疫反应分别有14例(70%)和17例(85%)。此外,9例(45%)为雄激素(AR)免疫反应阳性。在17例ESS和UES中,7例(41%)显示AR阳性。3例子宫内膜间质结节中2例也呈AR阳性。而且,3例高度恶性肉瘤(未分化子宫内膜肉瘤)中有1例ER和PR均为阴性,但AR为阳性免疫反应。结论在子宫内膜间质肉瘤中有AR表达(占45%),必将影响对这类病人的术后处理。 OBJECTIVE investigate whether the presence or obsence of androgen receptor（AR）. METHODS 20 tumor spccis were studied,including 3 endometrial stromal nodules, 14 low-grade endometrial sarcomas （ESS）, and 3 high-grade endometrial sarcomad （UES）. Immunohistochemical analyses for ER, PR, and Ar were performed on formalinfixed, paraffin-embedded archival material. RESULTS Positive immunoreactions for estrogen receptors and progesterone receptors were observed in 14 （70%） and 17 （85 %） cases, respectively, Furthermore, 9 cases （45%） were postive for androgen receptors. Among 17 ESS and UES cases, 7 （41%） revealed postivity for AR. Two of three begin stromal nodules were also positive for AR. Moreover,one of the three high grade sarcomas （undifferentiated endometrial sarcoma） was negative rot both ER and PR,but showed positive reaction for AR （45%）. CONCLUSION AR are expressed in endometrial stromal neoplasms（45%）. It must have some impact on the postoperative management of the patients.
作者 陈爱珠 陈秀清 谢兰琴
机构地区 福建省煤矿中心医院妇产科
出处 《海峡药学》 2006年第6期137-139,共3页 Strait Pharmaceutical Journal
关键词 子宫内膜间质内癌 雄激素受体 孕激素受体 雌激素受体 免疫组织化学 Endometrial stromal tumors Androgen receptor Estrogen receptor Progesterone receptor Immunohistochemistry
分类号 R977.1 [医药卫生—药品] R73 [医药卫生—肿瘤]
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海峡药学
2006年 第6期

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