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基质细胞衍生因子-1与糖尿病视网膜病变 被引量：2

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摘要 基质细胞衍生因子-1(SDF-1)与其特异性受体CXCR4构成的SDF-1/CXCR4轴具有广泛的生物学活性。对糖尿病视网膜病变的新近研究发现,循环中的造血干细胞及血管内皮祖细胞(EPC)在血管新生中起重要作用。视网膜缺血缺氧可引起缺氧诱导因子-1的增加,继而引起SDF-1表达上调。SDF-1与血管内皮生长因子及黏附分子等关系密切,还可破坏血-视网膜屏障,促进EPC在缺血缺氧的视网膜上产生新生血管,在糖尿病视网膜病变的发病机制中扮演重要的角色。
作者 袁源智 袁非
机构地区 复旦大学附属中山医院眼科
出处 《国际眼科纵览》 2006年第6期375-378,共4页 International Review of Ophthalmology
关键词 基质细胞衍生因子-1 糖尿病视网膜病变 发病机制 SDF-1 血管内皮祖细胞
分类号 R774.1 [医药卫生—眼科]
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参考文献10

  • 1Ceradini DJ,Kulkarni AR,Callaghan MJ,et al.Progenitor cell traffickingis regulated by hypoxic gradients through HIF-1induc-tion of SDF-1[].Nature Medicine.2004
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  • 3Butler J M,Guthrie SM,Koc M,et al.SDF-1is both necessary and sufficient to promote proliferative retinopathy[].The Journal of Clinical Investigation.2005
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同被引文献27

  • 1袁源智,袁非,黎蕾,汪洋,童蓓燕.基质细胞衍生因子-1在Wistar大鼠视网膜上的生理性表达[J].眼科研究,2007,25(7):518-521. 被引量：8
  • 2Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med, 2004,10:858-864.
  • 3Hattori K, Heissig B, Rafii S. The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Leuk Lymphoma, 2003,44:575-582.
  • 4Asahara T, Kawamoto A. Endothelial progenitor cells for postnatal vasculogenesis. Am J Physiol Cell Physiol, 2004,287:572-579.
  • 5Meleth AD, Agron E, Chan CC, et al. Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci, 2005, 46:4295 -4301.
  • 6Brooks HL, Caballero S, Newell CK, et al. Vitreous levels of VEGF and SDF-1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch Ophthalmol, 2004,112 : 1801-1807.
  • 7Butler JM, Guthrie SM, Koc M, et al. SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest, 2005,115:86-93.
  • 8Bursell SE, Clermont AC, Kinsley BT, et al. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci, 1996,37 : 886- 897.
  • 9Arjamaa O, Nikinmaa M. Oxygen-dependent diseases in the retina : Role of hypoxia-inducible factors. Exp Eye Res,2006,83 : 473-483.
  • 10Ozaki H, Yu AY, Della N, et al. Hypoxia inducible factor-la is increased in ischemic retina: temporal and spatial correlation with vegf expression. Invest Ophthalmol Vis Sci, 1999,40:182-189.

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国际眼科纵览
2006年 第6期

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