摘要
目的观察唾液腺黏液表皮样癌(MEC)术后生存率及不同临床分期患者的生存率,并确定影响术后生存的主要临床病理因素。方法对119例MEC按照临床流行病学关于预后研究的方法进行数据收集,乘积-极限法计算术后各时点的观察生存率,时序检验各临床病理因素对术后观察生存率的影响。结果119例唾液MEC患者术后总体的5、10、15年生存率分别为:92·53%、87·52%、85·39%。年龄≥40岁、TNMⅢ、Ⅳ期、低分化患者术后生存率分别显著低于年龄<40岁、TNMⅠ、Ⅱ期、高分化患者(P<0·05),大唾液腺MEC男性患者术后生存率明显低于女性(P=0·008)。分化程度、TNM分期及术前症状是进入Cox比例风险回归模型的3个对术后生存率有显著影响的主要因素。结论高分化型唾液腺MEC属于预后相对较好的恶性肿瘤,分化程度、TNM分期是影响患者预后的重要临床病理因素。
Objective The pathologic slides and clinical data of 119 patients with mucoepidermoid carcinoma （MEC） of salivary glands were reviewed. All patients underwent surgical therapy in Department of Oral and Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University. The postoperative overall observed survival rates and specific survival rates were statistically caculated, and the correlative clinicopathologic factors influencing the prognosis were evaluated. Methods Statistical analysis was performed using the SPSS 10.0 software. The survival rates were obtained by the Kaplan-Meier method. The clinicopathologic parameters were evaluated using log rank test （univariate analysis ） and Cox proportional hazards regression model （multivariate analysis）. Results The overall observed survival rates of this group were 92. 53%, 87.52% and 85.39% at 5, 10 and 15 years respectively after surgical therapy. Univariate analysis demonstrated that the factors correlated with lower in survival rates were patient＇s age （≥40 years）, advanced clinical stage （TNM m, Ⅳ stage） and the poorly differentiated tumors （P 〈 0. 05 ）. The survival rates of male patients with MEC in the major salivary glands were significantly lower than those of female patients （ P = 0. 008 ）. The degree of differentiation, TNM stage and preoperative symptoms were three important prognostic factors that were selected into the Cox proportional hazards regression model. Condusions Most patients with highly differentiated MEC in salivary glands had a favorable outcome after receiving adequate surgical treatment. The degree of differentiation and the TNM stage of MEC in the salivary glands are two useful factors to evaluate the prognosis of these neoplasms.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2006年第12期709-712,共4页
Chinese Journal of Stomatology
关键词
癌
黏液表皮样
涎腺肿瘤
预后
Carcinoma, mucoepidermoid
Salivary gland neoplasms
Prognosis
