期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

冠心病患者NT-ProBNP与HS-CRP联合检测的临床意义 被引量：3

The Clinical Importance to Detect NT-proBNP Combined with hs-CRP in Coronary Heart Disease
下载PDF
导出
摘要 目的探讨冠心病患者中NT-proBNP与hs-CRP联合检测的临床意义。方法收集临床上冠心病患者并进行分组,其中AMI组25例,UA组20例,SA组25例;正常对照组10例,所有患者入院后均即刻进行NT-proBNP与hs-CRP的检测,并根据NT-proBNP与hs-CRP高低再进一步将所有患者分成低NT-proBNP/低hs-CRP;低NT-proBNP/高hs-CRP;高NT-proBNP/低hs-CRP;高NT-proBNP/高hs-CRP四组。结果高NT-proBNP/高hs-CRP组中AMI占绝大数比例,四种NT-proBNP、hs-CRP组成模式在AMI、UA、SA中分布差异具有统计学意义(P<0.05),AMI外周血NT-proBNP、hs-CRP浓度高于UA高于SA,差异具有显著性意义(P<0.05)。结论NT-proBNP、hs-CRP与冠心病病情严重程度相关,联合两者可以预测病情等级程度。 Objective To investigate the clinical importance to detect NT-proBNP combined with hs-CRP in coronary heart edsease. Methods Dividing all patients recruited into 3 groups：AMI group; UAgroup;SAgroup;the health control objects werechosed at the same time, the concertration of NT-proBNP and hs-CRP were detected when in patience, dividing all patients into low NT-proBNP/ low hs-CRP group; low NT-proBNP/high hs-CRP group; high NT-proBNP/low hs-CRP group; bigh NT-proBNP/high hs-CRP group morcvcr. Results The distributon pattern of NT-proBNP/hs-CRP composition show statistical difference in AMI, UA ,SA（ P 〈 0.05） ; concentration of NT-proBNP/hs-CRP in peripherial blood is higher than UA than SA（ P 〈 0.05）. Conclusion NT-proBNP, hs- CRP show relation with extent of CHD, combined with such two indexes can prognose the grade of CHD.
作者 宋春莉 刘斌 费瑜 陈宏勃
机构地区 吉林大学第二医院心血管内科
出处 《中国实验诊断学》 2006年第12期1432-1434,共3页 Chinese Journal of Laboratory Diagnosis
关键词 冠心病 NT-PROBNP HS-CRP coronary heart disease NT-proBNP hs-CRP
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献3

二级参考文献18

  • 1急性心肌梗塞溶栓疗法参考方案（1996年7月修订）[J].中华心血管病杂志,1996,24(5):328-329. 被引量：1321
  • 2[2]Mendall MA.CRP and its relation to cardiovascular risk factors:a population based cross sectional study [J].BMJ,1996,312:1 016～1 065
  • 3[3]Heibron LK.Energy restriction and weight loss on very-low-fat diets reduce CRPconcentrations in obese,healthy women [J].Arteriosder Thromb Vasc Biol,2001,21:968～970
  • 4[4]Ridker PM.Blood levels of C-reactive protein may predict heart attact and stroke risk in women as well as men[J].Circulation, 1998(on line)
  • 5[5]Rafan N,ridker PM.High-sensitivity C-reactive protein:a novel and promising marker ofconnary heart disease [J].Clin Chem,2001,47:403-411
  • 6[6]Ridker PM,Cushman M,Stampfer MJ,et al.Inflammation aspirin and the risk ofcardiovammlar disease in apparently healthy men [J]. N Eng Med, 1997,97:425～428
  • 7[7]Ridker PM,Buring JE,Shih Let al.prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women[J].Circulation, 1998,98:731 ～733
  • 8[8]Paul M,Ridker MD,Nader Rifai,et al.Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of tirst cardiovascular events [J].N Engl J Med,2002,347:1 557～1 565
  • 9[9]Liuzzo G, Biomucci LM,Gallimore JR,et al.The prognostic value of C-reactive protein serum amyloid A protein in severe unstable ang ina[j]. N Engl J Med, 1994,331:417～424
  • 10[10]Ferreiros Er,Boissonnet CP,Pizorro R, et al. The prognostic value of elevated C-reactive protein in unstable angina [j].Circulation, 1999,100:1 958～1 963

共引文献58

同被引文献25

  • 1金艳,曹克将.心率与人类心血管疾病的相关性[J].中华心律失常学杂志,2004,8(5):310-313. 被引量：10
  • 2叶任高,陆再英,谢毅,等.普通高等教育“十五”国家级规划教材[M]//内科学.第6版.北京:人民卫生出版社,2004:273.
  • 3James SK,Lindbck J,Tilly J,et al. Troponin2T and N-terminal pro-B- type natriuretic peptide predict mortality benefit from coronary revas-cularization in acute coronary syndromes:A GUSTO-IV Substudy[J]. J Am Coll Cardiol, 2006,48 : 1146-1154.
  • 4Wiviott SD,Cannon CP,Morrow DA,et al. Differential expression of cardiac biomarkers by gender in patients with unstable angina/non- ST-elevation myocardial infarction :a TACTICS-TIMI18 (Treat angina with aggrastat an determine cost of therapy with an invasive or con- servative strategy thrombolysis in myocardial infarction 18) substudy[J]. Circulation, 2004,109 : 508-516.
  • 5Ndrepepa G,B raun S,Mehilli J,et al. Plasma levels of nterminal pro- brain natriuretic peptide in patients with coronary artery disease and relation to clinical presentation ,angiographic severity,and left ven- tricular ejection fraction[J]. Am J Cardiol, 2005,95 : 553-557.
  • 6Rklund E,Jernberg T,Johanson P,et al. Admission NT proBNP and its inter action with admission troponin T and ST segment resolution for early risk stratification in ST-elevation myocardial infarction[J]. Heart ,2005,10 : 1136.
  • 7Lindahl B ,Toss H ,Siegbahn A,et al. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease[J]. N Engl J Med,2000,343 (16) : 1139-1147.
  • 8Sabatinc MS, Morrow DA, Delemos JA, et al. Multimarker approach to risk stratification in non- ST elevation acute coronary syndromes; simultaneous assessment of troponin I,C-reactive protein,and B- type natriuretic peptide[J]. Circulation, 2002,105 ( 15 ) : 1760-1763.
  • 9王欢,王岚峰.N-末端脑钠素原在急性心肌梗死中的应用价值[J].心血管病学进展,2007,28(6):983-986. 被引量：3
  • 10MAMANI M,HASHEMI S H,HAJILOOI M. Evaluation of fibronectin and C-reactive protein levels in patients with sepsis:a case-control study[J].Acta Medica Iranica,2012,(06):404-410.

引证文献3

二级引证文献19

中国实验诊断学
2006年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部