摘要
目的:观察以直肠滴注中药“冰黄液”治疗急性脑出血的临床疗效及其作用机理。方法:将急性脑出血中医属于“阳闭”证者72例,以患者的神志、语言及运动功能和出血量为观察指标;动物试验观察大鼠神经功能缺损评分、脑组织含水量及脑组织中MDA、SOD和血清中LDH、CK的等变化。结果:“冰黄液”直肠滴注给药能提高临床疗效,在苏醒神志、缩短疗程等方面优于单纯西药组;可显著改善脑出血大鼠神经功能缺损症状,降低脑组织含水量,降低血清中LDH,CK及MDA含量,提高SOD活性。结论:实验结果表明“冰黄液”对脑出血急性期大鼠脑组织损伤具有较好的保护作用。
Objective： To observe therapeutic effects of rectum instillation with Binghuang Liquid on the cerebral hemorrhage and its mechanism of action. Method ： In the clinical observation, 72 cases of cerebral hemorrhage belonged to the “yang bi” syndrome of TCM, the mind, language and motor function, bleeding volume of the patients were as the observing targets, in the animal experi- ment, the neurologic impairment score of rat, water content of brain tissue, MDA and SOD in brain tissue, LDH and CK in serum were observed. Result： Rectum instillation with Binghuang Liquid could improve the curative effects, it was better to come to mind and shorten the course of treatment that compared with pure western medicine group. It can improve the neurologic impairment symptoms of rat, decrease the water content of brain tissue, LDH and CK in serum, the content of MDA, increase the activity of SOD. Conclusion： Binghuang Liquid has a good protective effect on the injury of brain tissue of rat at acute term of cerebral hemorrhage.
出处
《中医药导报》
2006年第12期3-6,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湖南省卫生厅中医药科研基金资助项目(96321)
关键词
脑出血
中医药疗法
直肠滴注
临床观察
实验研究
Cerebral hemorrhage
Therapeutic method of TCM
Rectum instillation
Clinical Observation
Experimental study
