摘要
目的探讨化疗栓塞术后发生截瘫的病因、临床特点和预防。方法2003年3月-2005年2月共有2758例肝肿瘤患者施行经导管动脉化疗栓塞术(TACE),术后发生截瘫4例。本研究详细回顾手术过程和术后病程。结果4例患者TACE术后4 h内出现截瘫症状,截瘫发生率为0.145%,并在24～48 h症状进行性加重,5～7 d后病情逐渐平稳,2个月后症状明显改善。结论肝肿瘤患者多次栓塞化疗后及远处转移瘤行供血动脉化疗栓塞时需慎重,尽量预防脊髓动脉栓塞。
Objective To evaluate the pathophysiology of paraplegia during transarterial chemoembolization in liver cancer and investigate effective management and prevention for improving clinical situation and relieve major symptoms. Method 2758 patients accepted TACE procedure because of liver cancer（and/or combined with remote metastasis）, demonstrated 4 cases suffering from paraplegia（3 males, 1 female）since Mar. 2003 to Feb. 2005, with mean age of（51 ± 14）years old, The operative records and the clinical features after chemoembolization were summarized in detail. Results The incidence of paraplegia was 0.145%, with major symptoms of dysesthesia and hypokinesise emerging within 4 hours after TACE, and most symptoms aggravating gradually within 24 - 48 hours untill paraplegia appeared, and then turned to stabilization about 5 - 7 days, with their body functions partial recovery in 2 months. Conclusion More attention should be paied to prevent ectopic embolization of spinal cord vessels originating from extrahepatic collateral arteries during TACE or TAE.
出处
《介入放射学杂志》
CSCD
2006年第12期725-727,共3页
Journal of Interventional Radiology
关键词
肝肿瘤
治疗性栓塞
并发症
截瘫
Liver cancer
Transarterial chemoembolization
Complications
Paraplegia
