摘要
目的:探讨外周血网织红细胞百分比(Ret%)在实体瘤化疗后对骨髓抑制监测的临床意义。方法:利用SYSMEXXE-2100全自动血细胞分析仪在化疗前后不同时间测定患者的中性粒细胞以及Ret%。数据结果采用t检验和卡方检验分析。结果:在接受化疗的实体瘤患者中,Ret%的下降早于中性粒细胞计数下降。其中在化疗后第7天Ret%≤0.3%的群体中发生IV度骨髓抑制概率为71.4%,而在Ret%>0.3%群体中为8.3%,两者之间存在统计学差异(P<0.01)。结论:外周血网织红细胞百分比是实体瘤患者化疗后骨髓抑制预见与监测的有效可靠指标。
Objective To investigate the significance of peripheral reticulocyte percentage （Ret%） in monitoring bone marrow suppression after solid tumor chemotherapy. Methods The neutrophils count and peripheral reticulocyte percentage were detected by SYSMEX XE-2100 Automated Hematology Analyzer in different days before and after chemotherapy.The data were analyzed by test and chi square test. Results The percentages of pe- ripheral reticulocyte percentage（Ret%） in the solid tumor patients during chemotherapy decreased earlier than the amount of neutrophils.The ratio of grade IV bone marrow suppression was 71.4% in those Ret%≤ 0.3%, while that was 8.3% in those Ret%〉0.3%（the seventh day after chemotherapy）,which showed statistical difference （P〈 0.01）. Conclusion The percentage of peripheral reticulocyte percentage is an effective index to predict the suppression of bone morrow hematopoiesis during solid tumor chemotherapy.
出处
《安徽卫生职业技术学院学报》
2006年第6期18-19,共2页
Journal of Anhui Health Vocational & Technical College
关键词
实体瘤
化疗
网织红细胞
骨髓抑制
solid tumor
chemotherapy
reticulocyte
bone marrow suppression
