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经皮肺穿刺注射无水乙醇治疗肺癌的动物实验和初步临床应用 被引量:24

Animal Experiment and Clinical Preliminary Application of Percutaneous Ethanol Injction Therapy in Lung Carcinoma
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摘要 目的:评价肺癌无水乙醇注射治疗的疗效。材料与方法:(1)7只健康家兔和14只大白鼠肺癌模型肺内注射无水乙醇,标本作病理检查;(2)在动物实验基础上,24例肺癌在透视导引下,经皮肺穿刺注射无水乙醇治疗,每个肿块治疗2~7次,间隔时间7~30天。结果:标本病理表现为非特异炎症,坏死,纤维化和癌巢周围癌细胞退变。临床上有效率为85.7%,未发现严重并发症。结论:经皮肺穿注射无水乙醇是安全、有效、易于操作的治疗肺癌方法。 Objective: The purpose of this study was to evaluate therapeutic effect of percutaneous ethanol injection (PEI) therapy in lung carcinoma. Materials and Methods: (1) PEI in the lung of health rabbits (7 cases) and rats with lung cancer model (14 cases) was performed, all specimens were studied with pathology; (2) On the base of animals experiment, 24 patients with lung carcinoma were treated with fluoroscopy guided PEI. Every mass was treated by PEI for 2~7 times. Intrval times were 7~30 days. Results: Pathological findings of the specimens showed nonspecific inflammation, necrosis, fibrosis and carcinous cell degeneration around cancer nest. The clinic effective rates were 85.7%. No severe complications occurred.Conclusion: PEI is safe, effective and easy to perform in the treatment of lung carcinoma. [HJ5mm〗
出处 《临床放射学杂志》 CSCD 北大核心 1996年第4期239-241,共3页 Journal of Clinical Radiology
关键词 动物实验 肺肿瘤 无水乙醇 WT5”BZ〗Animal, experiment Lung carcinoma Injection therapy Ethanol Lipiodol
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