摘要
Objective To evaluate the best dosages,orders of administration and effects of opioids on the cardiovascular responses to tracheal intubation.Methods 135 patients undergoing elective surgery and requiring general anesthesia were randomized to 9 groups,15 patients in each group.We designed the orders of the induction drugs in each group to make all the drugs would reach the peak concentration at the time of intubation.MAP,HR,CI and SVRI were recorded.Results MAP decreased in all the groups except R1 after induction of anesthesia(P<0.05) and increased after intubation,but not exceed the basic values,and MAPs in R2 and R3 were still lower than baseline(P<0.05).There wasn’t obvious changes in HR in all the groups except S2 after induction;after intubation,HR in all the groups increased slightly,but only HR in S2 exceed baseline significantly(P< 0.05).CI in all the groups decreased slightly after anesthesia induction.SVRI in all the groups decreased slightly after anesthesia induction,but only changes in F2 had statistical sense;at 1min after intubation,SVRIs weren’t kigher than the baseline.Conclusion Opioids combined with propofol are used in the induction of anesthesia,on the effect of restraining the cardiovascular responses,it is more important to choose the reasonable orders of administration of the anesthetics than the kinds or dosages of opoids.
Objective To evaluate the best dosages, orders of administration and effects of opioids on the cardiovascular responses to tracheal intubation. Methods 135 patients undergoing elective surgery and requiring general anesthesia were randomized to 9 groups, 15 patients in each group. We designed the orders of the induction drugs in each group to make all the drugs would reach the peak concentration at the time of intubation. MAP, HR, CI and SVRI were recorded. Results MAP decreased in all the groups except R1 after induction of anesthesia （P 〈 0.05） and increased after intubation, but not exceed the basic values, and MAPs in R2 and R3 were still lower than baseline （P 〈 0.05）. There wasn＇t obvious changes in HR in all the groups except S2 after induction; after intubation, HR in all the groups increased slightly, but only HR in S2 exceed baseline significantly （P 〈 0.05）. CI in all the groups decreased slightly after anesthesia induction. SVRI in all the groups decreased slightly after anesthesia induction, but only changes in F2 had statistical sense; at 1 min after intubation, SVRIs weren＇t kigher than the baseline. Conclusion Opioids combined with propofol are used in the induction of anesthesia, on the effect of restraining the cardiovascular responses, it is more important to choose the reasonable orders of administration of the anesthetics than the kinds or dosages of opoids.
出处
《国际麻醉学与复苏杂志》
CAS
2006年第6期338-340,共3页
International Journal of Anesthesiology and Resuscitation
