摘要
目的:观察FOLFOX4方案治疗国人晚期胃癌的临床疗效和耐受性。方法:35例晚期胃癌患者接受FOL-FOX4方案化疗,即:奥沙利铂85mg/m2,静脉滴注2h,d1;醛氢叶酸200mg/m2,静脉滴注2h,d1、d2;氟尿嘧啶400mg/m2,快速静脉滴注,d1、d2,600mg/m2,持续静脉滴注20h,d1、d2。每2周重复。治疗4～6周期后按WHO实体瘤疗效评定标准评价疗效及毒副反应。结果:全组35例均可评价疗效,总有效率48.6%(17/35)。其中,初治11例,CR1例,PR6例,有效率63.6%;复治24例,无CR,PR10例,有效率41.7%;初治与复治的疗效之间有统计学意义(P<0.05)。17例获缓解者的中位缓解期为7个月。毒性主要为胃肠道反应、末梢神经毒性、骨髓抑制及静脉炎等,未见因毒副反应而终止治疗者,无治疗相关性死亡。结论:FOLFOX4方案治疗国人晚期胃癌近期疗效确切,毒副反应较轻,多数患者耐受良好,值得临床进一步试用。
Objective： To observe the efficacy and safety of FOLFOX4 regimen for patients with advanced gastric cancer. Methods：There were 35 patients with advanced gastric cancer, and 28 men, 7 women respective. FOLFOX4 regimen： OXA 85 mg/m^2 iv 2h d1 , LV 200mg/m^2 iv 2h followed by 5-FU 400mg/m^2 iv bolus and 5-FU 600mg/m^2 iv 20h d1-2 , repeated every 2 weeks. Efficacy and side-effects were evaluated after 4 -6 cycles. Results：Thirty-five patients have been entered into the study. ORR 48. 6%. One of naive patients achieved CR （ 2. 9% ）, 16 PR （45.7%）, Secondary remedy patients achieved 0 CR, 10 PR. Overall response rate （ORR） for chemotherapy naive （ 1 s, line） and pretreated （ 2^nd line） patients were 63. 6% （ 7/11 ） and 41.7% （ 10/24 ） , respectively. The two groups had significant difference. Median time to progress （mTTp） was 7 months. The main toxicity was the toxicity of nausea/vomiting, myelosuppression, neutropenia and thrombocytopenia. There were no deaths during treatment. Conclusion： FOLFOX4 is a high response regimen for advanced gastric cancer with mild toxicity, which can be practiced safely.
出处
《临床肿瘤学杂志》
CAS
2006年第12期915-917,共3页
Chinese Clinical Oncology
关键词
胃肿瘤
化学治疗
奥沙利铂
醛氢叶酸
氟尿嘧啶
Stomach neoplasms
Chemotherapy
Oxaliplatin
Calcium folinate
Flurouracil.
