摘要
目的通过分析云南省18年出生缺陷的变化趋势,探讨今后的工作重点。方法按全国监测方案进行监测,对云南省近18年来出生缺陷监测结果进行回顾性分析。结果共监测围产儿341 406例,检出出生缺陷儿3 522例,围产儿出生缺陷发生率平均为103.16/万;全省出生缺陷发生率呈下降→上升→下降趋势;多指(趾)、唇腭裂(包括单纯腭裂、唇裂、唇裂合并腭裂)、神经管畸形、马蹄内翻足、肢体短缩畸形是云南省高发的前五位畸形;近10年来出生缺陷发生率呈现城市高于农村;出生缺陷发生率男性高于女性;母年龄≥35或≤20岁出生缺陷发病风险增加。结论应针对云南省高发严重畸形进行深入的病因学研究,同时提高出生缺陷产前及产后的诊断水平,做好出生缺陷的三级预防。
Objective By analyzing changing trend in birth defects （BD） over a 18 -year period in Yunnan province, to find out focus for future prevention of birth defects. Methods According to the National Criteria of BD Monitoring, the monitoring results for BD in recent 18 years in Yunnan province were analyzed retrospectively. Results 341406 perlnatal infants were monitored and 3 522 neonates with BD were identified, the average incidence rate of BD was 103.16 per ten thousand neonates. The incidence rate of BD appeared a decreasingrising- decreasing trend. The first five BD included polydactylia, cheikoschisis/uranoschisis （including simple cheikoschisis, simple uranoschisis and cheikoschisis associated with uranoschisis）, neural tube defect, equinovarus and shortening deformity of extremity. For recent 10 years, the incidence rate of BD in urban areas was higher than that in rural areas, and that in male infants was higher than in female infants. The risk of BD was higher in those pregnant women aged more over 35 years or below 20 years. Conclusion Futher etiological investigation on severe BD in Yunnan province should be done so as to raise the prenatal and postnatal diagnosis levels of BD and strengthen the tertiary prevention of BD practically.
出处
《中国妇幼健康研究》
2006年第6期456-459,共4页
Chinese Journal of Woman and Child Health Research
关键词
围产儿
出生缺陷
监测
预防
perinatal infant
birth defect
monitoring
prevention
