FLIP、Caspase 8及MTA1在上皮性卵巢肿瘤中的表达及其临床意义被引量：1

Expression of FLIP,Caspase 8 and MTA1 protein in epithelial ovarian tumor and its clinical singnificance

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摘要目的:研究凋亡抑制蛋白FL IP,C aspase8,肿瘤转移相关基因M TA 1在上皮性卵巢肿瘤中表达及其意义,探讨它们与卵巢癌临床病理指标之间的关系。方法:应用免疫组化SP法,检测FL IP、C aspase8、M TA 1在98例上皮性卵巢肿瘤(包括18例良性囊腺瘤,20例交界性囊腺瘤和60例卵巢癌)的表达情况。结果:FL IP、C aspase8及M TA 1在卵巢交界性囊腺瘤和卵巢癌中的表达均分别明显高于卵巢良性囊腺瘤(P<0.05),FL IP、M TA 1的表达在组织学分型、分化程度之间无显著性差异(P>0.05)。而与卵巢癌的F IGO分期及有无转移之间有显著性差异(P<0.05)。并且FLAP和C aspase8成负相关关系。结论:FL IP、M TA 1在卵巢癌中的发生发展中起重要作用。期望能为判断卵巢癌的生物学行为,决定治疗方案提供理论依据。 ObjectiveTo investigate the expression of FLIP ,Caspase 8 and MTA1 in human epithelial ovarian tumor and analyze its clinical significance. Methods：The expression of FLIP,Caspase 8 and MTA1 was detected by immunohisloehemical techniques in 48 patients with epithelial ovarian tumors （18 benign, 20 borderline and 60 malignant ones）. Results：The expression of FLIP, Caspase8 and MTA1 showed a significant difference between benign and borderline or malignant tumors （ P〈0. 05 ）. The expression of FLIP and MTA1 had difference between the FIGO stage and metastasis（ P 〈0.05） . There was a negative correlation between FLIP and Caspase 8. Conclusion：Overexpression of FLIP and MTA1 in ovarian tumor may play an important role in tumor development and progression. Detection of the FLIP,Caspase 8 and MTA1 may have potential effects on biological behaviors of the tumor,providing the theoretical basis for therapy.

作者刘一璇吕敬媛卢北燕

机构地区佳木斯大学临床医学院佳木斯大学附属第一医院妇产科

出处《黑龙江医药科学》 2006年第6期34-35,共2页 Heilongjiang Medicine and Pharmacy

关键词上皮性卵巢肿瘤 FLIP CASPASE8 MTA1 免疫组化 epithelial ovarian tumor FLIP Caspase8 MTA 1 immunohistochemistry

分类号 R737.31 [医药卫生—肿瘤]

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1Thome M,Schneider P,Hofmann K,et al.Viral FLICE inhibitory proteins(FLIPs) prevent apoptosis induced by death receptors[J].Nature,1997,386(6624):517-521
2Pencil SD,Toh Y,Nicolson GL.Candidate metastasis associated genes of the rat 13762NF mammary adenocarcinoma[J].Breast Cancer Res Treat,1993,25(2):165-174
3IRMLER M.Inhibition of death receptor signals by celluar FLIP[J].Nature,1997,388(6624):190-195
4Ryu BK,Lee MG,Chi SG,et al Increased expression of c-FLIP (L) in clinical adenocare inoma[J].J Pathol,2001,194(1):15-19
5Bullani RR,Huard B,Viard-Leveugle I,et al.Selective expression of FLIP in malignant malanocytic skin lesions[J].J Innest Dermasol,2001,117(2):360-364
6Lee SH,kim HS,Kim SY,et al.Increased expression of FLIP an inhibitor of fas-mediated apoptosis,in stomach cancer[J].APMIS,2003,111(2):309-314
7Toh Y,Oki E,Oda S,et al.Overexpression of the MTA1 gene on gastrointestinal carcinomas correlation with invasion and metastasi[J].Int J Cancer,1997,74(4):459-463
8Toh Y,Kuwano H,Mori M,et al.Overexperssion of metastasis associated MTA1 mRNA in invasive oesophageal carcinomas[J].Br J Cancer,1999,79(11-12):1723-1726
9Igwchi H,Imura G,Oh Y,et al.Expression of MTA1,a metastasis associated gene with histone deacetylase activity in pancreatic cancer[J].Int J Oncol,2000,16(6):1211-1214