摘要
目的:比较舍曲林和阿米替林治疗抑郁症的疗效及不良反应。方法:选择符合中国精神疾病分类方案与诊断第3版有关抑郁发作诊断标准的患者60例,随机分成2组:舍曲林组(30例)和阿米替林组(30例)。分别口服舍曲林20mg·d-1和阿米替林50mg·d-1,依病情可以调整40mg·d-1和250mg·d-1,用HAMD、TESS分别进行病情和副反应评定。结果:舍曲林和阿米替林的抗抑郁起效时间及疗效相近,舍曲林组有效率76.7%,阿米替林组为70.0%(P>0.05),舍曲林主要不良反应是食欲减退和恶心呕吐。结论:舍曲林的抗抑郁作用与阿米替林相似,但不良反应轻,用药方便,对海洛因依赖者脱毒后期出现的抑郁有一定的治疗价值。
Objective： To compare the antidepressant effects and adverse reactions ofsertraline and amitriptiline in treating depression. Methods： 60 patients meeting the CCMD-3 diagnostic criteria for depression episode were randomly divided into two groups. Thirty patients were treated with sertraline with starting dose of 20 mg. d＂l, increased to 40 rag·d^-1 p.o. The other thirty patients were treated with amitriptiline with starting dose of 50mg·d^-1, then 250 mg·d^-1 p.o. The patients were scored using HAMD and TESS. Results： The overall effective rate of sertraline and amitriptiline were 76.7% and 70.0%, respectively. The adverse reactions of sertraline were lighter than those of amitriptiline. The major adverse reactions of sertraline were anorexia and nausea. Conclusion： The antidepressant effects of sertraline and amitriptiline are similar, but adverse reactions of sertraline are lighter and more convenient to administer.
出处
《中国药物滥用防治杂志》
CAS
2006年第5期272-274,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
舍曲林
阿米替林
抑郁症
Sertraline
Amitriptiline
Depression
