摘要
目的:探讨连续性静-静脉血液滤过(continuous venovenous hemofiltration,CVVH)对严重脓毒症患者血流动力学和外周血辅助性T细胞亚群Th1/Th2平衡的影响。方法:前瞻性观察应用CVVH治疗18例严重脓毒症患者,于CVVH治疗前和治疗后4、8h抽取静脉血应用流式细胞仪检测外周血辅助性T细胞亚群Th1/Th2比值变化,同时观察生化指标、血流动力学变化。结果:18例患者CVVH治疗后血清BUN、Scr较治疗前均呈下降趋势(P<0.01),MAP显著上升(P<0.01),而多巴胺、去甲肾上腺素用量显著降低(P<0.01),Th1/Th2比值呈上升趋势,差异具有统计学意义(P<0.05或P<0.01)。结论:CVVH能改善严重脓毒症患者血流动力学及免疫麻痹状态。
Objective： To study the effects of continuous venovenous hemofihration （CVVH） on the hemodynamics and the balance of Th1-Th2 in severe sepsis. Methods： Eighteen severe septic patients were treated with CVVH. Th1/Th2 of peripheral T helper T cell were measured before and 4 and 8h after CVVH treatment. Blood biochemical indexes and hemodynamics parameters were observed. Results： BUN and Scr decreased significantly （P 〈 0.01）, MAP increased significantly （P 〈 0.01）, the dose of dopamine and norepinephrine decreased significantly （P 〈 0.01）, and Th1/Th2 increased after CVVH treatment in 18 patients. The differences were significant （P〈 0.05 or P〈 0.01）. Conclusion： CVVH can improve the hemedynamics and the immunosuppression in severe septic.
出处
《天津医药》
CAS
北大核心
2006年第12期866-868,共3页
Tianjin Medical Journal
